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Overview POSITION SUMMARY: The Nonhuman Primate Reagent Resource (NHPRR) under Diogo Magnani of the UMass Chan Medical School is looking for a full-time Associate Director to support the mission and establishment of a new preclinical biomanufacturing production core.
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We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development.
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To meet the Program's distinct and growing needs, the successful candidate will be responsible for the management of in-vitro and in-vivo preclinical ADME/PK for novel drug candidates; supervising and managing students, post-doctoral researchers and research technicians.
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The Senior Technician willexecute experiments, and will also be responsible for performing or collaborating in vivo PK/PD studies done in preclinical models including ex vivo assays (i.e. ELISA based PD read outs.
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AmplifyBio is a leading contract research organization with a comprehensive range of services that span from being an outsourcing partner for discovery stage R&D work, a preclinical CRO performing safety efficacy and toxicology studies for small molecules and advanced therapies alike, and, most recently, an expansion into manufacturing services for cell, gene, and mRNbased therapeutics.
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Provide in vitro biology and pharmacology support and collaborate with other drug discovery functions to advance preclinical programs and achieve company milestones. Leadership of the discovery biology team to in the development of strategies for internal target discovery and validation, assay development, and screening effort strategies that will drive project medicinal chemistry and deliver key elements of the development candidate project profile.
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Analyze and interpret a wide range of information (including clinical and preclinical data, scientific literature, and diverse expert views) to form independent viewpoints. 3+ years of experience in buy-side / sell-side equity research, healthcare industry, investment banking, consulting, venture capital and/or private equity.
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Manages multiple project teams in preclinical and clinical development. Ideally additional experience in a regulatory, translational medicine, clinical science, DMPK or other drug discovery roles.
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Develop, set-up, and utilize bench and preclinical models to evaluate performance of innovative bioabsorbable therapies. Apply sound engineering principles and practices to the design, development, and testing of biomaterials-based, drug delivery implants, and their delivery systems.
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You will be responsible for oversight and interaction with consultants and CROs assigned to support clinical pharmacology tasks including preclinical PK, modeling, and clinical assay development.
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The successful candidate will be responsible for designing and executing preclinical discovery research activities in collaboration with cross functional project teams for drug development candidates.
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Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD.
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Assessments of API and preclinical formulations. PhD. in Pharmaceutical Chemistry, Materials Science, Medicinal Chemistry with 5+ years, MSc. with 8+ years, or BS with 10+ years of experience in small molecule drug substances and drug products.
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Contribute as local SME to the design, execution and interpretation of preclinical safety, biocompatibility, analytical chemistry, and toxicological evaluation strategies and programs according to relevant regulatory requirements; including review of literature and assessment of compliance.
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Provide medical support and insights to internal stakeholders, including preclinical teams, regulatory affairs, and clinical operations and also external stakeholders, including supporting business development meetings.
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