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Position Summary: The Senior Technician in the Discovery Technologies In vivo pharmacology group will be part of a dynamic group of scientists conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer.
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At 1910 Genetics, we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, genetics, data science, and software engineering to develop drugs for previously undruggable targets.
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The Senior Technician willexecute experiments, and will also be responsible for performing or collaborating in vivo PK/PD studies done in preclinical models including ex vivo assays (i.e. ELISA based PD read outs.
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Comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development with a strong publication record. PhD in a subject area with a significant component of analysis and quantitation, such as systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, pharmaceutical sciences or applied mathematics with a minimum of 3 publications in peer reviewed journals.
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Mosaic teams provide comprehensive, end-to-end discovery services, including program assessment and strategy development; program management; antibody discovery and optimization; protein production, purification, and characterization; protein engineering; biochemical and cellular assay development; formulation, stability and developability studies; bioanalytical (PK and PD) assay development; and candidate-validating pharmacology.
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Strong medicinal chemistry and drug design knowledge with a solid understanding of ADME/PK, biology, and pharmacology principles. Stablix is a venture-backed preclinical stage drug discovery company, pioneering an entirely new field of targeted deubiquitination therapeutics to bring transformative medicines to patients with high unmet medical need.
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Cancer biology, immunology, molecular biology, bioinformatics) with 0-2 years’ experience in drug discovery or drug development. Plan, design, and execute IND-enabling pharmacology, pharmacokinetic and toxicology studies by applying knowledge of disease-associated pathways, preclinical models, and drug development.
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Quantitative Systems Pharmacology (QSP) & Physiologically Based Pharmacokinetics (PBPK) have become important components of discovery and clinical development. Maintain an active relationship with colleagues in Clinical Pharmacology, Pharmacometrics, & Bioanalysis at the project level as well as in the advancement of Pharmacometrics.
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The Department of Pharmacology at Northwestern University Feinberg School of Medicine seeks a full-time tenure track Investigator at the rank of Associate or full Professor with expertise in the structural biology of membrane proteins who will have opportunities to work in a collegial and collaborative scientific environment that is rich with core facilities, robust cross-disciplinary graduate training programs, and diverse expertise that is especially strong in receptor and ion channel biology.
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Specifically, we are seeking candidates to prosecute plate-based pharmacology, cell culture, enzymology, cell engineering and drug discovery experimental plans for our rapidly advancing pipeline.
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Pharmacology Product Development and Commercialization This course provides students with a working knowledge of the drug discovery, development, and commercialization processes. Topics include drug discovery and development, aspects of commercialization, health technology assessment and cost-effectiveness analysis; personalized medicine, pharmacogenomics, and companion diagnostics; drug pricing and reimbursement; governmental and private payers.
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Establish and maintain collaborations with cross-functional teams such as in-vivo pharmacology, bioinformatics and DMPK simulation to ensure alignment on scientific rationale and data generation to help define PK/PD/efficacy relationships.
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It is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations.
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The successful candidate will lead a pharmacology team and contribute expertise to discovery research activities aimed at generating novel botulinum neurotoxins and biotherapeutics. The Toxin Innovation Pharmacology Group at AbbVie is seeking a Principal Scientist who is highly motivated and innovative, and possesses strong leadership and communication skills to lead a neuromuscular junction in vivo research team.
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Responsibilities:We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.
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