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In this role, the candidate will work collaboratively and cross-functionally with colleagues to develop molecular methods (PCR) and Next-Generation Sequencing (NGS) workflows that support the surveillance, diagnostics, and research efforts of the California Department of Public Health.
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We utilize a range of techniques, including biochemical and molecular biology methods, next-generation sequencing (including single-cell sequencing), and genome editing to study these processes in cell culture, mouse models, and patient-derived models.
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Responsibilities include cell culture and maintenance of human cell lines, basic molecular biology (PCR, cloning, running DNA and protein gels), flow cytometry, preparation of samples for deep sequencing, confocal microscopy, basic statistical calculations, and other duties as assigned.
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Experience working with Next-Generation Sequencing Data. Experience building NGS pipelines in a clinical setting. Computational skills using Python and/or R. Ideal candidates will possess: Experience in cancer genetics, immunology, and/or molecular biology.
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Demonstrated expertise in molecular biology techniques, including DNA/RNA extraction & purification, NGS library preparation & QC, PCR, qPCR, etc. PhD or MS degree with 3-4+ years of professional experience in molecular biology, biotechnology, or biochemistry.
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Good understanding of genomics, molecular biology, and technologies such as qPCR and next-generation sequencing. Strong background in molecular/cellular biology, immunology, and/or virology, including "bench" experience.
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Functional understanding of cellular biology, molecular biology, DNA/RNA purification. The ideal candidate will demonstrate innovative approaches when designing, optimizing, and implementing Next-Generation Sequencing (NGS) or cell- and organoid-based workflows on automated robotic systems.
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Preferred Education, Experience and Skills: In-depth knowledge in molecular biology, next-generation sequencing technologies and prior experience with lab automation. Must have in-depth knowledge in molecular biology, next-generation sequencing technologies.
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These studies will utilize systems biology, including large-scale technologies (CRISPR/RNAi, proteomics/chemoproteomics, chemical biology, NextGen Sequencing, etc.) , as well as fundamental virology and more traditional cellular/molecular biology and biochemistry-based approaches.
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Knowledge of molecular biology techniques, such as nucleic acid extraction, PCR, and sequencing including next generation sequencing (NGS) is recommended and working experience and understanding of molecular bioinformatic pipelines, accreditation requirements, and lab quality protocols and procedures is preferred.
$64,885 a yearTemporaryExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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The incumbent will have solid technical knowledge and hands-on experience with molecular biology such as DNA purification, analytical and preparative gel electrophoresis, enzymatic manipulation, PCR, sequencing, and molecular cloning; experience can be from work during undergraduate education.
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You will work under the general supervision of the Laboratory Manager or Director, ensuring accurate and timely execution of laboratory protocols and procedures related to the clinical molecular pathology and genomics laboratory.
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Familiarity with next-generation sequence data analysis tools● Basic understanding of molecular biology and next generation sequencing is highly preferred● Familiarity with single cell data analysis is preferred, but not required.
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Experience with single-cell RNA, ATAC and/or multiome-sequencing data, spatial single cell approaches, molecular biology, and analyses that integrate genomic variation is extremely important (dGTEx), and analysis of large datasets is preferred.
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The Senior QC Scientist is an on-site role located in San Jose, CA.How you will make an impact:In this role, you will work as part of the QC team and responsible for effectively managing the QC process of Reproductive Health Technology (RHT) and Next Generation Sequencing (NGS) product portfolio.
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