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Knowledge of yeast fermentation and metabolism. Wet chemistry laboratory skills (pipetting, buffer preparation, filtration, dilution, stoichiometry) Participate in/drive fermentation and/or purification of proteins/VLPs at lab and pilot scale.
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This position will report to the Technical Operations Department and will support the manufacture of HPV Gardasil as part of a multidisciplinary team, the candidate will have a fundamental knowledge of fermentation and cell culture, protein chemistry and purification, analytical techniques and/or laboratory operations.
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Operation of production fermenters and associated control systems, and oversight of fermentation process. Filtration, washing and sampling of bacteria thought downstream processing. Disassembly, cleaning, and reassembly of fermentation equipment.
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Experience performing fermentation or cell culture studies at the labs scale. Experience performing fermentation or cell culture studies using shake flasks. Experience working with tangential flow filtration processing – microfiltration/ultrafiltration.
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Knowledge of biotechnology operations such as, Aseptic Filtration Systems, Fermentation Process, Inoculation Process, Chromatography Columns, TFF step etc. Knowledge of biotechnology operations such as, Aseptic Filtration Systems, Fermentation Process, Inoculation Process, Chromatography Columns, TFF step etc.
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Initially, this person will be responsible for understanding the Base Alcohol fermentation and Hard Cider, Tea, and Seltzer blending processes. Base Alcohol Processing – Coordinate the processing of Base Alcohol through centrifuge and filtration operations.
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Upstream processes include tissue culture, cell bioreactors, fermentation, virus propagation, cell and virus bank production, and buffer/media preparation. Downstream unit operations include harvest, clarification, chromatography, centrifugation, TFF (UF/DF), filtration, formulation, and fill-finish.
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Experience with Cell growth, Fermentation and Purification (Tangential Flow Filtration) for anaerobic bacteria strains is highly desirable. Perform in-process QC testing and inspection such as Gram stain check and Yield check by CFU.Establish Standard Operating Procedures (SOPs) and specifications for various manufacturing activities such as microbial Inoculum, Fermentation and Purification processes.
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Bachelor's or Master's degree from an accredited institution with a relevant scientific discipline such as Chemistry, Biology, Biochemistry, Molecular Biology, Protein Chemistry etc. Must be able to adhere to applicable biosafety and chemical hygiene practices when on the manufacturing floor or in laboratories.
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Tasks to be completed may include fermentation, protein purification, solvent extractions, tissue culture, preparation of bulk solutions, aseptic fills of buffers, filling and labelling of vials under sterile and non-sterile conditions, routine buffer and media preparation, filtration, vial preparation, and sterilization.
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Prior experience with controls systems supplied with skidded equipment utilized in fermentation, cell separation and recovery, filtration, CIP, and clean utilities preferred. Sr. Automation Engineer(Delta V)SUMMARYSr∯*∯ Automation Engineering position will be responsible for supporting Capital Delivery team the delivery of DeltaV and other Automation System in BioMarin, Novato, CA. The position will be in the Automation Engineering Group under the California Engineering and Facilities Service (CFE) Department.
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Monitor all plant activities on fermentation, filtration, transfer and storage operations and schedule activities to fit within plant staffing guidelines and product requirements. Aptitude to learn fermentation and mechanical/electrical plant systems.
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Bachelor’s degree in a Scientific, Engineering or Biotech field with years’ experience with upstream (fermentation/bioreactor) biologic production processes under GMP compliance. Ability to work with bioreactor operation and cell culture including aseptic technique Execute and monitor critical processes supporting mammalian, microbial, and fill finish production facilities Solid experience with the following: large-scale centrifuges, washers, autoclaves Performs the weighing, dispensing of raw materials for media and buffers Performs the preparation of small and large volume media and buffer solutions, filtration and transfer of product.
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Commit to creating a diverse and inclusive workplaceThis position will report to the Technical Operations Department and will support the manufacture of HPV Gardasil as part of a multidisciplinary team, the candidate will have a fundamental knowledge of fermentation and cell culture, protein chemistry and purification, analytical techniques and/or laboratory operations.
$32 - $34 an hourExpandApply NowActive JobUpdated 6 days ago - UpvoteDownvoteShare Job
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Join our Process Development Team in using a variety of fermentation techniques, purification techniques, and characterization methods to support commercial and bench scale pharmaceutical processes.
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