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Utilizes professional knowledge of: theories, principles, methods, and techniques of immunology, cell biology, and microbial pathogenesis, such as ELISA, ASC assays, cellular proliferation assays, western blotting, cell culture, small animal handling (such as mice or guinea pigs), and aseptic technique.
$50 - $65 an hourFull-timeRemoteExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Assist in the evaluation of Shigella vaccines in clinical and pre-clinical studies to include immunizing small animals, collecting blood, lymph nodes mucosal washes, and determining the immune response elicited after vaccination using cellular proliferation, antibody secreting cell (ASC), ELISA, and immunobead multiplexing assays.
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Cell based assays in cell plates, ELISA, Fluorescence detection with microplate reader, Cell culture aseptic techniques, handling, storage and maintenance of primary and cell lines, Cell transfection, lipid-based and/or magnetofection and handling of plasmids, Antibody-based cell separation techniques using magnetic columns.
$68,000 - $81,600 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Experience in a regulated, commercial GMP biomanufacturing environment (relevant experience may include media and buffer preparation, cell culture, fermentation, aseptic processing, chromatography, TFF, final formulation, and fill/finish.
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Essential duties would be to; employ recombinant protein expression and purification from E. coli and mammalian cells; protein characterization using chromatography, ELISA and BLI; plasmid manipulation, mutagenesis and sequence analysis; antibody display and engineering.
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Take routine analytical measurements for cell growth, gas-content analysis, pH, osmolality, nutrient and metabolite measurements and HPLC analysis of monoclonal antibody titers. Perform routine tasks such as media/buffer preparation, thawing of cryopreserved cells, cell culture passaging, aseptic sampling and banking competently and independently to support ongoing projects in cell culture lab.
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Solid understanding of the various unit operations of aseptic manufacturing such as bulk freeze thaw, compounding/mixing, filtration, filling and lyophilization for liquid and lyophilized products.
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Summary Visterra, Inc., needs a highly motivated Senior Research Associate with research experience in biochemistry, immunology and/or molecular biology to help further our antibody-based drug discovery programs.
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Visterra, Inc., is seeking a highly motivated Research Associate with research experience in biochemistry, cellular and/or molecular biology to help discover and develop biologic therapeutics, as well as expand platform technologies that support our antibody-based drug discovery programs.
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Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. You have experience in commissioning, qualification and validation activities associated with aseptic processes, technology transfers and new product commercialization.
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Immunology, Laboratory, biochemistry, glp, gmp, biology, elisa, antibodies, aseptic technique, iso 13485, Chemistry, assay development, assay. -Antibody purification, protein conjugation and labeling.
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Basic knowledge in the use of laboratory techniques such as sterile and aseptic techniques, buffer, and large- and small-scale protein purification. Demonstrated knowledge in cell culture techniques is required, as well as a basic knowledge of antibody and protein production methods.
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Participate in the construction and screening of immune-based libraries through immunization, antibody display, and flow cytometry. Aseptic technique and culture of mammalian, insect, and/or yeast.
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5-10 years of cGMP environment, aseptic processing, mammalian cell culture, monoclonal antibody, cell processing, cryopreservation or similar experience. 5-10 years of cGMP environment, aseptic processing, mammalian cell culture, monoclonal antibody, cell processing, cryopreservation or similar experience.
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Monoclonal antibody formulation development, aseptic operation experience, be familiar with analytical tools for drug product development such as, not limited to, SE-HPLC, UV/vis spectroscopy, viscosity determination, and knowledge and experience of compendia assays, especially particulate analysis, including micro flow imaging.
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