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We are seeking a highly motivated scientist to join a group that is engineering new AAV therapeutic vectors for lead indications and for evaluating advanced Gene Therapy technologies. We are investigating the use of Adeno-Associated Virus (AAV) vectors to deliver therapeutic proteins to patients for disease prevention as well as treatment of retinal, neuro, and infectious diseases.
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Senior Downstream Production Engineer, AAV Bioprocessing and Development (DSP) Ginkgo is looking for a highly motivated Senior Downstream Production Engineer, Cell and Gene Therapy to join the Foundry’s expanding High-throughput Screening (HTS) team.
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We developed novel adeno-associated virus (AAV) capsid variants that target kidney epithelial cells and are combining this technology with CRISPR-Cas gene editing to develop one-time curative treatments for PKD and other genetic kidney diseases.
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Experience with vaccine and/or viral vector (AAV, Adenovirus, and/or Lentivirus) production. This includes areas of vaccine, viral vector, and cell therapy process development and production. You will need in-depth knowledge of bioprocess and cell therapy markets as well as technical R&D trends.
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The drug product team is also investing in building new platforms to support complex formulations such as lipid nanoparticles, Antibody Drug Conjugates and AAV and other non-viral vector delivery.
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Responsibilities Representative responsibilities will include, but not necessarily be limited to, the following: Collaborate with research, analytical development and process development teams to develop, qualify/validate AAV gene therapy cell-based biological potency assays, protein chemistry assays, and molecular biology assays for process monitoring and drug product release, specifically SDS-PAGE, western blot, droplet digital PCR or qPCR, culture of primary mammalian cells, and cell.
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The overall research program for the Hoffman Lab is developing novel immunotherapies for autoimmune diseases through immune tolerance induction, Regulatory T cells (Tregs) and adeno-associated virus (AAV) gene therapy.
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We are seeking a highly motivated and talented scientist with background in cellular and molecular biology and assay development to join the Biotherapeutics and Genetic Medicine organization to support in vitro pharmacology work related to Genetic medicine research on AAV.
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BS/MS with 15+ years of relevant experience or PhD in Chemical Engineering or Biological/Biochemical sciences with 10+ years of relevant experience in AAV gene therapy. The successful candidate will lead and manage a team of process and analytical development scientists responsible for the development, optimization and characterization of AAV manufacturing platform to supply our next generation AAV vectors supporting early and late-stage development programs.
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Experience with high throughput molecular cloning techniques, AAV transductions and CRISPR is advantageous. Experience with CRISPR-Cas gene editing systems and AAV transductions desired.
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Proven expertise in downstream process development for viral vectors, with a focus on AAV and lentiviral vectors. Design, optimize, and scale-up downstream processes for the purification of viral vectors, with a focus on AAV and lentiviral vectors.
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Establish and lead the strategic gene therapy AAV vector engineering roadmap and provide exemplary scientific leadership for the company’s AAV research programs to support the overall corporate strategy.
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5+ years of experience in academia, biotechnology, or pharma industry with a primary focus on understanding AAV biology and discovery and preclinical development of gene therapy products. Looking for a highly motivated team member with deep expertise in AAV biology and application to gene therapy, with a demonstrated track record of successful research to development transitions of gene-based therapies.
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Expertise in biologics Purification development such as nucleic acids protein, and/or AAV. Sail's platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time.
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The Head of Cell Line Development will oversee the manufacturing process of novel viral vector plasmids, as well as the development of packaging and/or producer cell lines for AAV. The incumbent will lead the cell line development strategy and work cross-functionally with teams to advance the viral gene therapy pipeline.
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