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Work directly with supervision to design and lead execution of experiments at benchtop scale for research, development, and evaluation of novel cell culture processes and scale-up of AAV technology platform.
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Actively contribute to programs to enhance AAV development and manufacturing technologies/ capabilities and work-processes (such as media development, feed development, bioreactor fed-batch and perfusion process development, optimization and scale-up.
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Responsibilities -Develop assays for GMP release of gene therapy products-Develop assays for product characterization of gene therapy products-Develop assays for AAV/protein/DNA to assist in evaluation of process change, formulation andstability study-Report project status (development plans, timelines, and results) to supervisor and technical teams.
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Priority will be given to those candidates also with some experience in molecular genetic (e.g., RNAseq, qRT-PCR) and/or viral targeting approaches (e.g., AAV). This is a unique opportunity for a highly motivated and independent-minded individual to merge research between the two labs, whose goals are to understand the neurophysiological circuit and molecular genetic bases of learning, memory and cued action.
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Familiarity with gene therapy approaches using AAV and lentiviral vectors would be preferred. Hematology / Oncology Staff Research Associate I/II Division of Hematology/Oncology. The research program in the Gaensler laboratory focuses on the application of genetic engineering strategies for the treatment of hematologic disorders, development of stem cell transplantation approaches, and for design of immunotherapeutic strategies for the treatment of acute myelogenous leukemia.
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Preferred Qualifications: Experience in handling, formulating, processing, and characterizing gene therapy drug product, such as adeno-associated virus (AAV) and lipid nanoparticles (LNPs). Department/Position Overview:The Principal Research Associate (PRA) will be a member of the Biologics Drug Product Development & Manufacturing (BioDPD-M) group within the global CMC organization.
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You will participate in process development programs focused on vector engineering, facilitating translation from small scale to large scale AAV production in support of current and future therapeutic programs.
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The individual in this position will be responsible for assisting with biological experiments semi-independently in accordance with manager approval in the area of AAV cell-line and process development for gene therapy production.
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Experience in single cell technologies for transcriptomics; flow cytometry (or other forms of cytometric analyses); cellular histology and confocal microscopy especially live-cell imaging; and AAV design, production and in vivo animal validation are particularly desirable skills.
$92,802 a yearFull-timeExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Research Associate/Associate Scientist (Ocular Biologist) - Contract Redwood City, CA Research Contract. Adverum is a clinical stage AAV-based gene therapy company targeting unmet medical needs in ocular and rare diseases.
$65 an hourFull-timeExpandApply NowActive JobUpdated 1 month ago - UpvoteDownvoteShare Job
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Lead research in the mass production of oncolytic vaccina virus, and Adeno-Associated Virus (AAV) using the HDCR bioreactor. Mass production of oncolytic vaccina virus, Adeno-Associated Virus (AAV), and stem cells; operation of HDCR bioreactor to produce Poxviruses, AAV, and stem cells; chromatographic purification of AAV gene therapy vectors; gradient-based purification of AAV and oncolytic vectors; and in vivo potency testing of AAV and oncolytic vectors required.
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The individual will support analytical testing and related activities conducted within Process Analytics laboratory, Technical Operations to accelerate the process development for AAV derived gene therapy products.
$85,000 a yearFull-timeExpandApply NowActive JobUpdated 8 days ago - UpvoteDownvoteShare Job
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The company offers a growing portfolio of purification solutions for a wide range of biologics, including AAV, lentivirus, mRNA, plasmid DNA and other viral particles. As a Research Associate in the Reagent Development team, you will support the development and scaling of IsoTag™ reagents by producing smaller scale lots for testing and further development.
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Perform Quantitative Polymerase Chain Reaction (qPCR), Droplet Digital PCR (ddPCR), Immunoassays, In Vitro Potency, and additional AAV characterization assays. Designs and performs method validations and analytical testing to support release and stability testing of AAV based gene therapy products.
$95,000 a yearFull-timeExpandApply NowActive JobUpdated 15 days ago - UpvoteDownvoteShare Job
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Job Title: Research Associate/Sr. Research Associate, AAV gene therapy (Contract position) The Research Associate/Sr. Research Associate will join the ocular team at client Genomic Medicine Unit to provide bench-facing expertise in support of gene therapy programs for ophthalmology indications.
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aav job Title: research associate
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