Agenus

UK Cell Line Development Team Leader. Lead end-to-end Cell Line Development for pipeline projects, including activities from vector design and construction to clonal cell lines and Research Cell Banks (RCB) ready for Master Cell Bank generation.. Comprehensive understanding of cellular biology and biopharmaceutical cell line development.. Significant experience and understanding of gene editing tools, CRISPR, Cre-recombinase, etc.. Background in cell and molecular biology, with experience in host cell engineering, cell culture process development, vector development, and/or development of novel analytical methods to aid in cell line generation.

development team leader

**UK Cell Line Development Team Leader**     Location    **Cambridge, UK**      Employment duration    **Full time**      ID    **583**       * Responsible for the generation of stable, high-expressing cell lines for biologics production for subsequent transfer into process development and cGMP manufacturing.
* Lead end-to-end Cell Line Development for pipeline projects, including activities from vector design and construction to clonal cell lines and Research Cell Banks (RCB) ready for Master Cell Bank generation.
* Leading UK team and UK work packages for the program to develop a proprietary and flexible CHO host Cell & Vector System for internal pipeline biologics manufacturing.
* Expected to contribute significantly to the direction of the cell line engineering team, designing overall strategy, and ensuring seamless implementation into CLD platform processes. Developing and establishing traceable and regulatory compliant engineered manufacturing mammalian cell lines.
* Expected to contribute to the design and implementation of early manufacturability assessments to identify liable molecules from panels of lead drug candidates, to ensure any DTE molecules are suitable for cell line generation and bioprocessing before entering the mCLD pipeline.
* Responsible for the generation of stable cell lines for target expression and reporter cell lines in support of target evaluation and discovery research.
* Expected to directly manage a growing team of scientists and senior scientists, setting goals and objectives and ensure the delivery of projects on time.
* Drive process improvements for increased speed and efficiency.
* Work cross-functionally to develop and establish new techniques and recommend alternative approaches and potential solutions to cell line issues.
* Deliver cell line history and CLD documentation and reports ensuring appropriate quality of documentation, cell line segregation and materials traceability to support inclusion of data and information in regulatory filings.
* Ensure a healthy and safe working environment and compliance to GMO/ACDP requirements.
* 10+ years of direct industry experience
* Comprehensive understanding of cellular biology and biopharmaceutical cell line development. (required)
* Significant experience and understanding of gene editing tools, CRISPR, Cre-recombinase, etc. for the generation of cell lines. (required)
* Background in cell and molecular biology, with experience in host cell engineering, cell culture process development, vector development, and/or development of novel analytical methods to aid in cell line generation. (required)
* Understanding of the regulatory requirements on the quality of biotechnological/biological products and derivation and characterisation of cell substrates used for production of biotechnological/biological products. Experience with the preparation of regulatory submissions. (required)
* Experience with controlling product quality by cell engineering and/or cell line selection
* Experience with automation and high-throughput technologies as applied to mammalian cell line generation and process optimization
* Experience in a range of cell line selection and screening methodologies
* Good knowledge and understanding of NGS/Omics
* Lab management, ensuring appropriate levels of control over scientific data, equipment, and materials, maintaining appropriate levels of documentation, record keeping, and procedures.
* An accomplished leader, with strong team-building skills and the ability to collaborate and deliver across multi-disciplinary projects.
* Innovative and natural problem solver; able to join the dots of disparate information sets.

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