Singular Genomics

In addition, the company is currently developing the G4X™ Spatial Sequencer, an upgrade to the G4, which will leverage Singular’s proprietary sequencing technology, applying it as an in situ readout for transcriptomics, proteomics and fluorescent H&E in tissue, with spatial context.. Our Headquarters are located on the Torrey Pines Mesa, in La Jolla, California at the center of the biotech hub.. Support/participate in integration tests (imaging, fluidics, software, general automation) on the system.. PhD in Biomedical Engineering, Biophysics, Chemistry, Biochemistry, or related field + min of 2 yrs in industry or postdoc.. Experience in several of the follow areas: spatial transcriptomic, advanced fluorescence microscopy, micro-fluidics, bio-conjugation techniques, surface chemistry, DNA sequencing, programming language(s) and molecular biology.

integration

About Singular Genomics Singular Genomics is inventing at the forefront of genomics, one of the world’s fastest-growing industries. The commercially available G4® Sequencing Platform is a powerful, highly versatile benchtop genomic sequencer designed to produce fast and accurate results. In addition, the company is currently developing the G4X™ Spatial Sequencer, an upgrade to the G4, which will leverage Singular’s proprietary sequencing technology, applying it as an in situ readout for transcriptomics, proteomics and fluorescent H&E in tissue, with spatial context. Singular Genomics’ mission is to empower researchers and clinicians to advance science and medicine. We foster a culture of creativity and technical excellence, both catalysts for innovation. We celebrate diversity, emphasize collaboration and, as we rapidly mature, we are constantly looking at ways we can do better for our people. Our Headquarters are located on the Torrey Pines Mesa, in La Jolla, California at the center of the biotech hub. Our Manufacturing facility is in Sorrento Valley. This role reports to our HQ location. POSITION SUMMARY:  As a Systems Integration Scientist 2, working at the center of our highly skilled and seasoned scientific and engineering teams, you will have the opportunity to experience a highly collaborative, cross-functional and multi-disciplinary work environment. Dynamic and fast-paced, you will stretch your abilities identify and create solutions to challenging problems. This role requires a true self-starter; an individual with a strong desire to solve problems with a demonstrated track record of doing so; someone who holds themselves and their work to high standards, can provide examples of strong scientific rigor in their work. This person will be meticulous, organized, and thorough and utilize a systematic approach to project management. You will supervise more junior associates while driving experiments to completion. Responsibilities <ul><li>Design and execute complex experiments to further develop G4X Spatial Sequencer. Support/participate in integration tests (imaging, fluidics, software, general automation) on the system.  </li><li>Identify, troubleshoot, and analyze system issues that have been found during integration testing including but not limited to molecular biology, hardware and software performance. </li><li>Collect and analyze numerical and image data using analytical tools (e.g., Excel, Python, JMP, ImageJ), document and present results to the team.  </li><li>Report on system integration progress, test results and the system’s functional, performance and reliability capabilities.  </li><li>Qualify new product designs through design verification tests.  </li><li>Translate high-level requirements into subsystem requirements, create performance budgets.  </li><li>Implement and execute integration and test strategy: which items are needed in which order to perform stepwise integration.  </li><li>Coordinate with the engineering and R&D groups and external vendors responsible for the delivery of the subsystems, including the verification of sufficient subsystem performance.  </li><li>Completing documentation to support testing procedures including data capture, forms, logbooks, and inventory batch records.  </li></ul>Qualifications:  <ul><li>PhD in Biomedical Engineering, Biophysics, Chemistry, Biochemistry, or related field + min of 2 yrs in industry or postdoc. </li><li>Strong experimental laboratory skills, demonstrated by work experience.  </li><li>Ability to define problems, collect data, establish facts, and draw valid conclusions.  </li><li>A minimum of 5 years of relevant experience in integration activities, e.g. as an integrator in a multidisciplinary project.  </li><li>Experience in several of the follow areas: spatial transcriptomic, advanced fluorescence microscopy, micro-fluidics, bio-conjugation techniques, surface chemistry, DNA sequencing, programming language(s) and molecular biology.  </li><li>Desire and ability to work in a small interdisciplinary team to develop new technologies at a rapid pace.  </li><li>Proficient at designing and running tests to evaluate the functionality and performance of systems comprising imaging, illumination, electrical, mechanical, vacuum and fluidic modules and subsystems.    </li><li>Understanding of manufacturing test including how and what to test for production and engineering design verification.  </li><li>Familiar with scripting languages. Ability to write scripts for quantitative analysis of large data sets and automated testing.   </li></ul>The estimated base salary range for this role based in the United States of America is: $94,600 - $133,200. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data. Should the level of the role change during the hiring process, the applicable salary range may be updated accordingly. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. Singular Genomics is an equal-opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Singular Genomics is committed to working with and providing reasonable accommodations to job applicants with physical or mental disabilities. Applicants with a disability who require a reasonable accommodation for any part of the application or hiring process can provide their name and contact information to our Accommodations team at accommodationsrequest@singulargenomics.com. Your request will be responded to as soon as possible. Please note: Singular Genomics does not accept agency resumes and is not responsible for any fees related to unsolicited resumes. Please do not forward resumes to Singular Genomics employees.

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