AbbVie

In Vivo Pharmacology - Immuno-oncology (Senior Scientist I/II). Our expanding In Vivo Pharmacology group in South San Francisco, CA has an opening for a motivated biologist with a focus on immuno-oncology particularly T cell biology, who is dedicated to the discovery and development of innovative therapeutics, both small molecule and biologics.. The scientist will work collaboratively in a project team setting with biology, medicinal chemistry, biologics, and DMPK scientists to advance oncology programs through the R&D pipeline.. Designs and executes/conducts in vivo studies (e.g. syngeneic, humanized mouse models, GEMMs, adoptive transfer systems) aimed at drug discovery in the immuno-oncology space. Knowledgeable of secondary ex vivo cell-based assays across various technology platforms (e.g. FACS/cell sorting, imaging, ELISA/MSD, western blot/WES, IO-related culture systems, and omics-based approaches such as scRNseq) to assess target modulation levels and downstream effects at cellular, protein and gene level.

senior scientist i

<p>Company Description</p>
<p>AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.</p>
<p>Job Description</p>
<p>In Vivo Pharmacology - Immuno-oncology (Senior Scientist I/II)</p>
<p>Our expanding In Vivo Pharmacology group in South San Francisco, CA has an opening for a motivated biologist with a focus on immuno-oncology particularly T cell biology, who is dedicated to the discovery and development of innovative therapeutics, both small molecule and biologics. The Senior Scientist I/II will design/perform tumor efficacy and PK/PD studies to understand how to effectively modulate the innate and adaptive immune system for new therapies. The scientist will work collaboratively in a project team setting with biology, medicinal chemistry, biologics, and DMPK scientists to advance oncology programs through the R&D pipeline.</p>
<h3>KEY RESPONSIBILITIES</h3>
<ul>
<li>Designs and executes/conducts in vivo studies (e.g. syngeneic, humanized mouse models, GEMMs, adoptive transfer systems) aimed at drug discovery in the immuno-oncology space</li>
<li>Uses detailed knowledge of state-of-the-art tools and approaches to enhance in vivo evaluation of novel therapeutics mechanism of action and/or identify new targets.</li>
<li>Participates in oncology target identification and validation.</li>
<li>Demonstrates a high level of initiative in troubleshooting experiments and performing data analysis.</li>
<li>Effectively collaborates across all intra and cross functional teams.</li>
<li>Presents research findings to project teams and governance bodies and prepares technical reports.</li>
<li>Works with external academic, biotechnology, and contract research organizations to advance our understanding of oncology diseases.</li>
<li>Understands and adheres to IACUC protocols regarding animal welfare and handling.</li>
<li>Mentors and guides other scientists in the department; managerial experience preferred.</li>
<li>Commits to scientific rigor, high data quality and careful documentation.
*</li>
</ul>
<p>Qualifications</p>
<h3>Job Requirements</h3>
<ul>
<li>Senior Scientist I/II : PhD in Immunology or a related discipline with 0+ (Sr Sci I) or 4+ (Sr Sci II) years of relevant research experience.</li>
<li>Hands-on expertise to design and perform complex in vivo experiments utilizing tumor models in both immunocompetent and immunocompromised mice; proficient in cell/drug administration via different routes (SC, IP, PO, IV).</li>
<li>Knowledgeable of secondary ex vivo cell-based assays across various technology platforms (e.g. FACS/cell sorting, imaging, ELISA/MSD, western blot/WES, IO-related culture systems, and omics-based approaches such as scRNA-seq) to assess target modulation levels and downstream effects at cellular, protein and gene level.</li>
<li>Extensive knowledge of immuno-oncology and tumor biology with proven publication record.</li>
<li>Demonstrated excellence and productivity in independent research.</li>
<li>Strong written and verbal communication skills.</li>
<li>Scientific leadership abilities and collaborative personality.</li>
<li>Detail-oriented, with excellent organizational and record-keeping skills.
*</li>
</ul>
<h3>Preferred Requirements</h3>
<ul>
<li>PhD with 2+ years of experience in the pharmaceutical or biotechnology industry.</li>
<li>Hands-on experience and knowledge of humanized models, cell line-derived xenograft models, genetically engineered mouse models, adoptive immune cell transfer models, and/or in vivo genetic delivery platforms.</li>
<li>Extensive experience with T cell exhaustion, CAR-T, and in vivo targeted gene delivery.
*</li>
</ul>
<h3>Key Leadership Competencies</h3>
<ul>
<li>Ability to manage multiple responsibilities and meet deadlines in a fast-paced environment.</li>
<li>Entrepreneurial personality, with problem solving skills, critical thinking ability, and excellent communication skills.</li>
<li>Highly motivated and independent with an ability to adapt to changing priorities in a fast-paced environment.</li>
<li>Raises the bar and is never satisfied with the status quo.</li>
<li>Excited to participate in and contribute to company culture.</li>
<li>Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.</li>
<li>Learns fast, grasps the "essence" and can change course quickly where indicated.</li>
<li>Creates a learning environment, open to suggestions and experimentation for improvement.</li>
<li>Embraces the ideas of others, nurtures innovation and manages innovation to reality.</li>
</ul>
<p>Additional Information</p>
<p>Applicable only to applicants</p>

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