OpenEye, Cadence Molecular Sciences

Your work will have the potential to make a major impact in drug discovery, and will be available to many pharmaceutical and biotech companies.. OpenEye, Cadence Molecular Sciences – a division of Cadence Design Systems – is an industry leader in computational molecular design through rapid, robust, and scalable software, consulting services, and Orion®, the only cloud-native fully integrated software-as-a-service molecular modeling platform.. Combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in a customizable development platform, Orion offers unprecedented capabilities for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances.. Protein structure prediction in drug discovery. Graduate student in physics, chemistry, or a related STEM field

scientific software developer

Over the last eight years, OpenEye Scientific has developed the field’s most advanced large-scale compute platform, Orion, built on Amazon Web Services. In this position, you will be working at the cutting edge of cloud computing, C++/Python development, and advanced MD simulation techniques. Your work will have the potential to make a major impact in drug discovery, and will be available to many pharmaceutical and biotech companies. OpenEye, Cadence Molecular Sciences – a division of Cadence Design Systems – is an industry leader in computational molecular design through rapid, robust, and scalable software, consulting services, and Orion®, the only cloud-native fully integrated software-as-a-service molecular modeling platform. Combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in a customizable development platform, Orion offers unprecedented capabilities for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances. OpenEye, Cadence Molecular Sciences is headquartered in Santa Fe, N.M., with offices in Boston, Mass.; Cologne, Germany; and Tokyo, Japan. We are seeking a graduate-level intern to explore various aspects of protein structure prediction using machine learning algorithms and cryoEM data. The intern will join a scientific software development team with diverse background and knowledge on structural biology and high-performance computing. It will be a great chance to get familiar with AlphaFold and other similar packages, understand latest CryoEM techniques for 3D map reconstruction from 2D images, explore different ML algorithms for protein structure prediction, and cumulate software development experience on OpenEye’s cloud computing platform. Key Learnings:<ul><li>Protein structure prediction using machine learning algorithms and cryoEM techniques</li><li>Scientific software development practices: code review, pair programming, scientific validation</li><li>Protein structure prediction in drug discovery</li><li>Development experience on OpenEye’s cloud computing platform</li></ul> Education--What you should have (formally MUST HAVES/REQUIREMENTS):<ul><li>Python programming</li><li>Graduate student in physics, chemistry, or a related STEM field</li><li>Strong analytical skills</li><li>Basic knowledge of molecular biology</li></ul> The following are a PLUS, but not required (preferred skills/experience):<ul><li>Familiarity with the concepts of protein structure prediction</li><li>Basic knowledge of machine learning</li><li>Experience with protein structure prediction packages</li></ul>

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