MD Anderson Cancer Center

The primary purpose of the Research Investigator position is to supervise the scientific research laboratory projects, carry out laboratory research in vitro and in vivo projects, comprehending the role of radiation and DNA repair defects on immune response activation and radiosensitization.. Data Acquiring and Analysis Data evaluation and recording in concordance with methods requested.. Scanning of mIF slides for pathology image analysis, skills to operate the Vectra and Polaris system scanner to mIF slides and troubleshooting technical problems if necessary.. Develop novel techniques for Multiplexed IHC analysis of biomarkers on tissue samples.. Develop multiplexed IHC based techniques utilizing FFPE surgical specimens, core needle biopsies and smears from different tumor types to biomarkers analysis.

research investigator

The University of Texas MD Anderson Cancer Center in Houston is one of the world's most respected centers focused on cancer patient care, research, education and prevention. It was named the nation's No. 1 hospital for cancer care in & World Report's 2018 rankings. It is one of the nation's original three comprehensive cancer centers designated by the National Cancer Institute. The primary purpose of the Research Investigator position is to supervise the scientific research laboratory projects, carry out laboratory research in vitro and in vivo projects, comprehending the role of radiation and DNA repair defects on immune response activation and radiosensitization. Technical experience working with cell lines, mIF manual and automated staining and scanning, western blot, and assays. The RI must be able to provide technical and coordination skills in carrying out various research projects, coordinates procedures, estimates budgets, and performs technical laboratory duties in accordance with general and/or specific plans. Functions in a separate and independent manner in the design and initiation of research experiments. Designs, develops or adapts equipment used in experiments or research to obtain desired results. Determines specific goals or objectives to be obtained, evaluates research data and develops and revises techniques or approaches to work problems. Plans training and research work activity for assigned laboratory and research personnel. Supervises the use of laboratory equipment and implements safety procedures. Compiles, writes and submits project results to superiors. JOB SPECIFIC COMPETENCIES Operate Multiplex Immunofluorescence (mIF) staining on automated systems. Performance mIF validation, optimization, troubleshooting and staining using up to date techniques on manual and automated systems. Utilizes laboratory equipment to carry out experiments. Proficient in mIF techniques such as - Tyramine system (Opal kit 7 colors, Perkin Elmer), scanning Vectra/Polaris system and inForm image analysis system (Perkin Elmer) for study of immune profiling and immune checkpoints in formalin-fixed paraffin-embedded (FFPE) tumor tissues. Data Acquiring and Analysis Data evaluation and recording in concordance with methods requested. Scanning of mIF slides for pathology image analysis, skills to operate the Vectra and Polaris system scanner to mIF slides and troubleshooting technical problems if necessary. Develop novel techniques for Multiplexed IHC analysis of biomarkers on tissue samples. Develop multiplexed IHC based techniques utilizing FFPE surgical specimens, core needle biopsies and smears from different tumor types to biomarkers analysis. Performance research, update, and upgrade novel techniques for IHC including, mIF (MultiOmyx, Vectra), and multiplex RNAscope, for complex research projects involving immune profiling. Laboratory Maintenance and Project Coordination Maintains Lab Functions to include ordering of supplies and ensures lab equipment is maintained in good operating order. Project Coordination of all Multiplex immunofluorescence projects, including tracking of samples and reagents, supervision of research assistants, coordination with the pathologists, for projects including the department of translational molecular pathology, TMP-IL, APOLLO and Alliances initiatives. Other duties as assignedEducationRequired: Bachelor's degree in one of the natural sciences or related field. ExperienceRequired: Five years of experience in scientific or experimental research work. With preferred degree, three years of required experience. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.

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