AbbVie

AbbVie's Development Sciences organization invents chemical processes and prepares active pharmaceutical ingredient (API) to enable clinical trials, toxicology studies, and drug product development for AbbVie's pre-clinical and clinical drug pipeline.. Within Development Sciences, the Process Engineering group supports process design and tech transfer for small molecules and antibody drug conjugates (ADC).. Process Engineering also partners with Biologics CMC Development and Aesthetics R&D functions to provide active engineering support to enable robust process scale-up and manufacturing of biologics drug substances and drug products including toxins and cosmetic active ingredients.. As a member of the Center for Reaction Engineering, the selected candidate will have a strong background in chemical reaction engineering and is expected to address challenging problems with chemical reactions using expertise in chemical kinetics, transport phenomena, mathematical modeling, and reactor design.. The candidate is also expected to lead identification and development of novel technologies to enhance efficiency in process development, scale-up, and commercialization.

principal research scientist

Job Description AbbVie's Development Sciences organization invents chemical processes and prepares active pharmaceutical ingredient (API) to enable clinical trials, toxicology studies, and drug product development for AbbVie's pre-clinical and clinical drug pipeline. Within Development Sciences, the Process Engineering group supports process design and tech transfer for small molecules and antibody drug conjugates (ADC). Process Engineering also partners with Biologics CMC Development and Aesthetics R&D functions to provide active engineering support to enable robust process scale-up and manufacturing of biologics drug substances and drug products including toxins and cosmetic active ingredients . We create valuable intellectual property through composition of matter, chemical processes, and novel technologies resulting in cost effective commercial manufacturing processes. We develop the supply chain for APIs and prepare and defend CMC (Chemistry, Manufacturing, and Control) regulatory content. Process Engineers in AbbVie's R&D environment work in multi-functional teams to develop scalable processes and supply API for safety testing, clinical trials, and formulation development. Process Engineers support API projects through all phases of development. Early in development, engineers focus on ensuring that the process can be run safely and identifying and addressing scale-up issues. Later in the development process, engineers optimize the API process and lead process campaigns. In the final stage of development, engineers transfer the optimized process to manufacturing sites, develop control strateg ies, prepare reports to support regulatory filings, and support process validation. The successful candidate will play a key role in the Process Engineering function, specifically the Center for Reaction Engineering. The core deliverable of the function is to develop robust commercial processes to manufacture small molecule APIs, ADCs, and Aesthetics products . As a member of the Center for Reaction Engineering, the selected candidate will have a strong background in chemical reaction engineering and is expected to address challenging problems with chemical reactions using expertise in chemical kinetics, transport phenomena, mathematical modeling, and reactor design. The candidate is also expected to lead identification and development of novel technologies to enhance efficiency in process development, scale-up, and commercialization . Such technologies may include deployment of custom automation solutions, fit-for-purpose reactor configurations, and novel modeling approache s. The candidate must exhibit a collaborative nature in identifying process challenges on a wide range of projects, participate in a cross-functional team of chemists and chemical engineers to deliver specific project needs, and take on a leadership role in developing and implementing solutions. Key Responsibilities: <img src="https://www.jobg8.com/Tracking.aspx?%2faOfzdZVoN3zQKeDdEx8oAp" width="0" height="0" />

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