Houston Methodist Academic Institute

The Keith Syson Chan laboratory has assembled a highly supportive research environment for trainees, and is seeking a self-motivated, career goal-driven postdoc (at all levels) with enthusiasm in studying the epigenetic regulation of the immune TME in impacting immune checkpoint response [ Nature 517 : 209–213 (2015); Nature Communications 10 : 2131 (2019); Nature Communications 11 : 6299 (2020); Nature Communications 13 : 1487 (2022); J Natl Cancer Inst.. Our lab also has in-lab flow cytometry analyzer and sorter, spatial biology platforms (e.g., 10X Xenium, 10X CytAssist, Akoya PhenoCycler etc), proteomics profiling capacity, and ample fundings to integrate omics data with functional assays for research investigations.. EDUCATION Postdoctoral Fellow 0, 1, 2, 3, 4 - Doctor of Medicine (MD) from an accredited medical school or Terminal Degree in a related field (A letter from the academic institution certifying that all student work is complete will be considered for Postdoctoral Fellow 0 only.). The Education Institute also oversees continuing medical education and graduate medical education, and supports more than 1,000 trainees in residence for medical, nursing, allied health and research education programs.. Houston Methodist Research Institute supports research programs and infrastructure that enable faculty across the system to bring new scientific discoveries to patients as rapidly as possible through the full cycle of a cure from conceptual bench research, to prototyping and development, to clinical trials and FDA approval.

postdoctoral fellow

The Keith Syson Chan laboratory https://www.research4cure.org/ has assembled a highly supportive research environment for trainees, and is seeking a self-motivated, career goal-driven postdoc (at all levels) with enthusiasm in studying the epigenetic regulation of the immune TME in impacting immune checkpoint response [ Nature 517 : 209–213 (2015); Nature Communications 10 : 2131 (2019); Nature Communications 11 : 6299 (2020); Nature Communications 13 : 1487 (2022); J Natl Cancer Inst . 2022 114(10):1380-1391; Nature Reviews Urology 19 : 515–533 (2022)]. We have established tumor models representing hot and cold tumors with scRNAseq profiling and corresponding differential response to various treatment modalities. These data and models will form the foundation for project mining and experimental investigations. Our lab also has in-lab flow cytometry analyzer and sorter, spatial biology platforms (e.g., 10X Xenium, 10X CytAssist, Akoya PhenoCycler etc), proteomics profiling capacity, and ample fundings to integrate omics data with functional assays for research investigations. Candidates are highly welcome to bring their own ideas, those with at least one first author publication and expertise in epigenetics, or one of following research topics are highly encouraged to apply: Epigenetic regulation, chromatin modifications, ATAC-seq, scATAC-seq etc Cancer immunology and the immune TME Immunometabolism Molecular biology in various cell death mechanisms, e.g., ferroptosis, necroptosis, pyroptosis, inflammasome biology etc Mechanisms of immune exclusion and checkpoint resistance Postdoc candidates receive equal benefits as full-time Methodist employees. PEOPLE ESSENTIAL FUNCTIONS Assists the physician in maintaining the functionality and operations of the Principal Investigator's (PI) laboratory. Promotes a positive work environment and leads the team to be dynamic and a focused work unit that actively helps one other to achieve optimal department results. Collaborates with all members of the department by actively communicating and reporting data in a comprehensive manner. Role models to team members effective verbal, non-verbal and written communication, which includes active listening and teaching, assisting in development of such skills. Provides contributions towards improvement of department scores for employee engagement, i.e. peer-to-peer accountability. SERVICE ESSENTIAL FUNCTIONS Develops research methods and performs research activities. Documents research results and writes reports of results for presentation and/or publication in professional journals and other publications. QUALITY/SAFETY ESSENTIAL FUNCTIONS Follows all safety rules while on the job. Reports accidents promptly and corrects minor safety hazards. Communicates with peers and management regarding any hazards identified in the workplace. Assists with implementation and education of department-based safety initiatives, standards of practice and protocols. Develops skills of team members and continually assists with improving skills, performance and outcomes. Identifies opportunities for corrective action and process improvement providing recommendations and contributes to meeting department and laboratory targets for quality and safety. FINANCE ESSENTIAL FUNCTIONS Utilizes resources effectively and efficiently, demonstrating responsible financial stewardship. Manages own time effectively and prioritizes work to achieve maximum results in a timely manner. Uses resources efficiently; does not waste supplies. Self-motivated to independently manage time effectively and prioritize daily tasks. GROWTH/INNOVATION ESSENTIAL FUNCTIONS Participates in pertinent research activities and evidenced-based practice projects. Participates in departmental projects and activities. Acts as a change agent. Seeks opportunities to expand learning beyond baseline competencies with a focus on continual development. Remains current on professional issues and clinical skills. Completes and updates the My Development Plan on an on-going basis. Ensures own career discussions occur with appropriate management. This job description is not intended to be all-inclusive; the employee will also perform other reasonably related business/job duties as assigned. Houston Methodist reserves the right to revise job duties and responsibilities as the need arises. EDUCATION Postdoctoral Fellow 0, 1, 2, 3, 4 - Doctor of Medicine (MD) from an accredited medical school or Terminal Degree in a related field (A letter from the academic institution certifying that all student work is complete will be considered for Postdoctoral Fellow 0 only.) WORK EXPERIENCE Postdoctoral Fellow 0 - None Postdoctoral Fellow 1 - One year of Postdoc experience Postdoctoral Fellow 2 - Two years' Postdoc experience Postdoctoral Fellow 3 - Three years' Postdoc experience Postdoctoral Fellow 4 - Four years' Postdoc experience LICENSES AND CERTIFICATIONS - REQUIRED N/A KNOWLEDGE, SKILLS, AND ABILITIES Demonstrates the skills and competencies necessary to safely perform the assigned job, determined through on-going skills, competency assessments, and performance evaluations Sufficient proficiency in speaking, reading, and writing the English language necessary to perform the essential functions of this job, especially with regard to activities impacting patient or employee safety or security Ability to effectively communicate with patients, physicians, family members and co-workers in a manner consistent with a customer service focus and application of positive language principles Demonstrated knowledge of biomedical research Ability to work effectively in a fast-paced environment Demonstrates flexibility and adaptability in the workplace SUPPLEMENTAL REQUIREMENTS WORK ATTIRE Uniform No Scrubs Yes Business professional No Other (department approved) Yes ON-CALL Note that employees may be required to be on-call during emergencies (ie. DIsaster, Severe Weather Events, etc) regardless of selection below. On Call No TRAVEL Travel specifications may vary by department May require travel within the Houston Metropolitan area No May require travel outside Houston Metropolitan area No Company Profile: Houston Methodist Academic Institute oversees the Education Institute and Research Institute, including 772 faculty and 56,250 learners. The Academic Institute aligns our research and education initiatives in service to the clinical mission, providing solutions that answer the call for new technologies and skills our clinicians need for patient care. Houston Methodist Education Institute coordinates our primary academic affiliation with Weill Cornell Medicine and other joint programs, including the Engineering Medicine Program at Texas A&M University Intercollegiate School of Engineering Medicine. The Education Institute also oversees continuing medical education and graduate medical education, and supports more than 1,000 trainees in residence for medical, nursing, allied health and research education programs. Houston Methodist Research Institute supports research programs and infrastructure that enable faculty across the system to bring new scientific discoveries to patients as rapidly as possible through the full cycle of a cure from conceptual bench research, to prototyping and development, to clinical trials and FDA approval. The Research Institute supports more than 1,387 clinical research protocols and $70.3 million in extramurally funded translational research programs. Houston Methodist is an equal opportunity employer inclusive of women, minorities, disabled persons and veterans. Equal Employment Opportunity Houston Methodist is an Equal Opportunity Employer. Equal employment opportunity is a sound and just concept to which Houston Methodist is firmly bound. Houston Methodist will not engage in discrimination against or harassment of any person employed or seeking employment with Houston Methodist on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, status as a protected veteran or other characteristics protected by law. VEVRAA Federal Contractor – priority referral Protected Veterans requested.

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