Flagshippioneering

The current Flagship ecosystem comprises 41 transformative companies, including Denali Therapeutics (NASDAQ: DNLI), Indigo Ag, Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology (NASDAQ: SANA), Seres Therapeutics (NASDAQ: MCRB), and Valo Health.. The ideal applicant will be a scientist with a strong background in formulations including lipid nanoparticles (LNP) and/or polymer (PNP) vehicles and understanding of nucleic acid delivery and characterization.. The candidate will be responsible for supporting key formulation development for our eRNA platform encompassing nanoparticle design, characterization and optimization, in vitro/in vivo RNA formulation screening, exploring new delivery modalities and applications as well as other critical responsibilities.. Conduct laboratory formulation development and production of RNA drug targets (lipid and polymer nanoparticles, etc.). Demonstrated success in nucleic acid delivery and the development of diverse drug carriers with hands-on experience in lipid nanoparticle (LNP) formulations, polymer-based nanoparticles & characterization

formulation

**Company Summary:**Laronde is pioneering a platform that offers a completely novel way of modulating human biology. Endless RNA (eRNA), invented at Flagship Labs, is a uniquely engineered RNA that can be programmed to express diverse proteins inside the body. It is persistent, non-immunogenic, allows for repeat dosing, and offers flexibility in formulation and delivery. Laronde was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. Laronde has raised a record breaking $440 Million in a Series B Financing to advance the development of its eRNA platform and a broad pipeline of programs across a number of therapeutic categories. The company is rapidly scaling to support the parallel development of multiple programs across many disease areas. To learn more, please visit www.laronde.bio. We have 2 locations; 325 Vassar St. Cambridge, MA and also 101 South St. in Sommerville, MA.Laronde was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources and grows first-in-category life sciences companies. Since 2000, Flagship has created over 100 groundbreaking companies pioneering novel and proprietary biological, industrial and engineering approaches to solve major needs in human health and sustainability. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including Denali Therapeutics (NASDAQ: DNLI), Indigo Ag, Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology (NASDAQ: SANA), Seres Therapeutics (NASDAQ: MCRB), and Valo Health.**Position Summary:**Laronde is seeking a creative and scientifically rigorous Scientist to join our expanding team as a part of the platform group, to design and develop delivery strategies for our nucleic acid-based modality. The candidate must be independent and motivated, and able to work efficiently within a multi-disciplinary team. The ideal applicant will be a scientist with a strong background in formulations including lipid nanoparticles (LNP) and/or polymer (PNP) vehicles and understanding of nucleic acid delivery and characterization. The candidate will be responsible for supporting key formulation development for our eRNA platform encompassing nanoparticle design, characterization and optimization, in vitro/in vivo RNA formulation screening, exploring new delivery modalities and applications as well as other critical responsibilities. The position will support projects within a broad therapeutic platform.**Key Responsibilities:*** Conduct laboratory formulation development and production of RNA drug targets (lipid and polymer nanoparticles, etc.) for in vitro and in vivo studies* Develop and execute analytical methods to characterize RNA formulations including nanoparticle techniques and methods to assess purity and stability of the formulated molecules* Evaluate novel ideas for formulation optimization and increasing stability of formulations* Develop novel in vitro and in vivo assays for evaluating functionality, targeting efficiency and potency of novel delivery modalities* Work closely with CROs* Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams* Generate and support generation of IP for core projects**Qualifications:*** PHD in Chemistry, Chemical/Biochemical Engineering, Biochemistry, Pharmaceutical Sciences, or related discipline with 0-3 years of industry experience.* Demonstrated success in nucleic acid delivery and the development of diverse drug carriers with hands-on experience in lipid nanoparticle (LNP) formulations, polymer-based nanoparticles & characterization* Direct experience with RNA encapsulation/quantification/characterization/handling is preferred* Proficiency in analytical techniques like HPLC/UPLC, DLS, zeta potential, UV-Vis and fluorescence spectrophotometry etc. is preferred* Understanding and success in implementation of RNA-related analytics (Ribogreen assay, gel electrophoresis, capillary electrophoresis, etc.) is desired.* Strong analytical and problem-solving skills+ Action-oriented, team player, and highly motivated, with strong work ethic+ Excellent verbal and written communication+ Ability to excel in a fast-paced, dynamic, innovative environment+ Manage multiple projects concurrently and collaborate across disciplines Flagship Pioneering and our ecosystem companies are **committed to equal employment opportunity** regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. ***Recruitment & Staffing Agencies**: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, FSP) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneerings internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.*

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