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Drug Mechanism of Action Scientist
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Full-time
- PROGRAM DESCRIPTIONThe Frederick National Laboratory for Cancer Research (FNLCR) is a Federally Funded Research and Development Center sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. With more than 2,000 employees, the FNLCR is responsible for pursuing a mission of translational and applied biomedical research that is unique from academia, the pharmaceutical industry, or other federal contractors.
- The successful candidate will carry out experimental studies to elucidate the underlying mechanism of action (MOA) of novel oncology drugs and their combinations that have demonstrated strong, unexpected and inexplicable efficacy (, combination activity for Drug A plus Drug B despite the absence of Drug A’s target) in preclinical models and/or cancer patients.
- The scope of these projects will encompass employing computational skills to analyze existing NCI databases and other sources of preclinical and clinical study results to formulate MOA hypotheses that are testable with well-designed experiments on molecular targets, biochemical pathways, cellular responses, tumor heterogeneity, drug response and resistance, and immunological response (both innate and adaptive).
- It is also likely that wide-ranging experimental approaches will be required to test the MOA hypotheses, including enzymatic studies, labeling of cell types (, fluorescent markers or genetic barcodes), proteomics and single-cell RNA sequencing, spatial transcriptomics, and high-resolution tissue imaging.
- Contribute to the design, presentation, and coordination of necessary experimental work to fill knowledge gaps and then to directly test the MOA hypotheses, some of which research will be collaborative work within a team as well as with other groups, including the FNLCR Molecular Characterization Laboratory (MoCha), Proteomics Characterization Laboratory, Clinical Pharmacodynamic Biomarkers Program, and the NCI Biological Testing Branch.
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