BioSpace

About the Opportunity: The Senior Scientist is a part of the Downstream Bioprocess Development department and responsible for leading projects focused on developing, optimizing, and scaling purification processes for life science enzymes used in nucleic acid manufacturing and other applications.. Passionate about protein purification (including chromatography, bioprocess filtration, scale up, and optimization) and harnessing the power of enzymes to solve challenging real-world problems in the healthcare industry.. Leading development, hands-on execution, and optimization of protein purification processes including primary recovery unit operations (centrifugation, homogenization, flocculation, tangential-flow filtration (TFF), and depth filtration), chromatography (ion-exchange, affinity, hydrophobic interaction), and pre-formulation (TFF, dialysis).. Hands-on experience developing, executing, and optimizing protein purification processes, including chromatography, TFF, and bioprocess filtration unit operations.. The ability to rationally design and optimize purification processes, characterize enzymes, and interpret complex data sets based on a strong understanding of protein biochemistry.

sr scientist

Department 48 - Bioprocess Development Employment Type Full Time Location Redwood City, CA Workplace type Onsite Description Codexis, a biotechnology company based in Redwood City, CA, is looking to hire a Bioprocess Development Downstream Sr. Scientist. Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver® technology platform to discover, develop and enhance novel, high-performance enzymes and other classes of proteins. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis. The Company is currently developing its proprietary ECO Synthesis™ platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis enzymes can drive improvements, such as higher yields, reduced energy usage and waste generation, improve efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications. To meet the goals we’ve set for ourselves, we look for individuals who are driven, eager to grow and ready to embrace meaningful challenges. We empower employees to be authentic, ambitious, agile and have the courage to take action where they can make a positive impact. Come join us on this journey to transform the enzyme engineering landscape for the betterment of human health. About the Opportunity: The Senior Scientist is a part of the Downstream Bioprocess Development department and responsible for leading projects focused on developing, optimizing, and scaling purification processes for life science enzymes used in nucleic acid manufacturing and other applications. The Sr. Scientist will also be responsible for tech transfer activities for external manufacturing. They will grow and develop a small team of research associates and/or process engineers and will have the opportunity to work with and learn from a collaborative, knowledgeable team of scientists and engineers. This role will be based in Redwood City. If any of the below describes you, we would love to meet you! <ul><li>Passionate about protein purification (including chromatography, bioprocess filtration, scale up, and optimization) and harnessing the power of enzymes to solve challenging real-world problems in the healthcare industry.</li><li>Driven by scientific curiosity and devoted to continuous learning in a collaborative, supportive, and safety-focused team environment.</li><li>Ability to serve as a technical leader in the group, project management skills, and strong attention to detail.</li><li>Excellent interpersonal and communication skills to effectively communicate across cross-functional teams. </li></ul>In This Role You Will Be Responsible For <ul><li>Leading development, hands-on execution, and optimization of protein purification processes including primary recovery unit operations (centrifugation, homogenization, flocculation, tangential-flow filtration (TFF), and depth filtration), chromatography (ion-exchange, affinity, hydrophobic interaction), and pre-formulation (TFF, dialysis).</li><li>Leading scale-up and tech transfer of protein purification processes for external manufacturing under various regulatory systems (e.g. ISO13485, cGMP).</li><li>Executing, adapting, and troubleshooting analytical methods for protein characterization such as SDS-PAGE, HPLC, UV-Vis, colorimetric assays, SEC-MALS, DLS, etc.</li><li>Authoring key documents such as development reports and technology transfer packages.</li><li>Representing the Bioprocess Development team in cross-functional project teams and communicating data, results, and conclusions to scientists, project management, business development, and other stakeholders.</li><li>Following safety best practices and leading implementation of new safety procedures.</li><li>Mentoring and training a growing team of junior scientists, process engineers, and/or research associates. </li></ul>The Essential Requirements Of The Job Include <ul><li>Ph.D. in Biochemistry, Chemical Biology, Chemical or Biomolecular Engineering, or related discipline preferred, with a minimum of 5 years relevant experience; M.S. or B.S. with at least 8-10 years relevant experience, respectively.</li><li>Hands-on experience developing, executing, and optimizing protein purification processes, including chromatography, TFF, and bioprocess filtration unit operations.</li><li>The ability to rationally design and optimize purification processes, characterize enzymes, and interpret complex data sets based on a strong understanding of protein biochemistry.</li><li>Experience characterizing proteins using analytical methods such as activity assays, SDS-PAGE, HPLC, DLS, etc. with strong statistical rigor.</li><li>Experience with project management, including the ability to prioritize according to company goals and plan full development projects.</li><li>Experience preparing technical reports and communicating data to cross-functional audiences. </li></ul>Additional experience that would be valuable for this role includes: <ul><li>Mentoring and leading technical teams.</li><li>Experience using Design of Experiment (DOE) methodology for process development, including high-throughput purification and/or analytical methods.</li><li>Hands-on experience with protein recovery from microbial hosts</li><li>Experience with lyophilization, spray dry, pre-formulation, and/or oligo purification development. </li></ul>CODEXIS PAY TRANSPARENCY: The anticipated salary range for candidates who will work in Redwood City is $135,000 to $160,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Codexis is a multi-state employer, and this salary range may not reflect positions that work in other states . What can Codexis offer you? <ul><li>Medical, Dental and Vision Insurance </li><li>Basic Life, AD&D, Short- and Long-Term Disability Insurance </li><li>401k with Company Match up to 4% </li><li>Company Equity </li><li>Generous Paid Time Off including 18 Company Holidays (with a summer and winter shutdown), Vacation, and Wellness Time </li><li>Annual Lifestyle Account for reimbursement of fitness programs, equipment and more </li><li>Employee Stock Purchase Program (ESPP) </li><li>Flexible Spending Accounts (Commuter/Parking, Dependent Care & Healthcare)</li><li>Student Debt Program (Company Contribution to Loans)</li><li>Mental Health Wellness Program</li><li>Subsidized onsite lunch program</li><li>Onsite Gym Facilities</li><li>Paid Parental Leave</li><li>And More! </li></ul>About Codexis Inc Why join Codexis? At Codexis we offer a very competitive compensation package and beyond excellent benefits! We foster career growth, continued education and upskilling through our mentorship program and learning and development opportunities. You will learn and work alongside inspirational leaders and colleagues who are equally passionate about our mission and committed to fostering an inclusive, growth-centered, and rewarding culture. Diversity is valued and mutual trust is of paramount importance to the ethos at Codexis. The people, the culture and working with others with a common goal is what makes Codexis a great place to work. For more information, visit www.codexis.com. NO AGENCIES OR THIRD PARTIES Codexis is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.

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