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Medicinal Chemistry is responsible for leading drug design efforts across all small molecule projects of Internal Medicine Research Unit (IMRU) portfolio.. An experienced, highly innovative research scientist driving new directions in medicinal chemistry.. Provides leadership and vision for the creation of cutting-edge medicinal chemistry and drug discovery strategies for the diversity of diseases and organs of relevance for IMRU.. Is a key member of IM Medicinal Chemistry leadership team; contributes to the development and execution of the unit’s portfolio, provides scientific and inspirational leadership to the members of RU chemistry group and across Medicine Design, promotes a culture of innovation.. Strong working knowledge and track record of delivery in medicinal chemistry and drug discovery including delivery of candidates to Ph2 or beyond

internal medicine

ROLE SUMMARY
The Head of Design for Internal Medicine (IM)--Medicinal Chemistry is responsible for leading drug design efforts across all small molecule projects of Internal Medicine Research Unit (IMRU) portfolio. We are seeking a recognized scientific and people leader in medicinal chemistry with the following qualifications:
A robust track record of delivering projects into clinical trials.
An experienced, highly innovative research scientist driving new directions in medicinal chemistry.
Has a history of successfully developing talents and forging strong partnership across departments.
Has a strong track record of publications and presentations and viewed as a scientific leader in the field. ROLE RESPONSIBILITIES
Accountable for driving excellence in medicinal chemistry, drug design and drug discovery for IM Medicinal Chemistry: “Get the right molecule” with a balance of cost, speed and quality.
Ensure competitiveness of medicinal chemistry portfolio.
Expand druggable target capabilities.
Achieve >80% survival of selected compounds to First-in-human clinical studies. Delivers molecules that safely and effectively modify target function in patients that address unmet medical needs and differentiate from molecular therapies that are standard of care in the disease areas of relevance and focus for IMRU.
Provides leadership and vision for the creation of cutting-edge medicinal chemistry and drug discovery strategies for the diversity of diseases and organs of relevance for IMRU.
In partnership with IMRU leaders is responsible for the development and execution of a portfolio from idea to the clinic. Influences and partners effectively with IMRU leadership.
Designs and implements chemistry and chemical biology strategies that aid the evolution and execution of medically and commercially differentiated portfolios.
Leverages the strengths of the Medicine Design model and structure to build a sustainable industry leading organization.
Is a key member of IM Medicinal Chemistry leadership team; contributes to the development and execution of the unit’s portfolio, provides scientific and inspirational leadership to the members of RU chemistry group and across Medicine Design, promotes a culture of innovation. Drives the team and the department to set a standard of excellence for productivity, efficiency and delivery.
Together with IM Medicinal Chemistry Head of Synthesis, drives a culture of one chemistry team/department to efficiently deliver the portfolio.
Identifies, and executes to clear and successful outcomes, new opportunities for strategic collaborations (both external to the company and within Pfizer) to enable IMRU portfolio delivery and/or drive Medicine Design strategy.
Contributes and regularly leads the review of external assets for purposes of ascertaining in-license opportunities or competing compounds to drive strategic decision making.
Aligns and prioritizes medicinal chemistry resources to deliver Research Unit (RU) goals from idea to POC.
Accountable for building and evolving skills and resources to deliver RU chemistry plan. Embraces AI/ML generative chemistry and help developing/implementing modern design tools to accelerate delivery of clinical candidates.
Attracts, retains and develops talents to underpin organizational capability. Delivers the next generation of scientific Leaders in the Medicinal Design organization.
Influences the external environment through thought leadership and visible and active engagement with key opinion leaders, funding bodies, professional societies, and academic institutions to align research to areas of mutual interest and produce a talent pipeline with appropriate skills to meet organizational needs. MINIMUM QUALIFICATIONS
Ph.D. or advanced degree
8+ years of related experience in a large or medium pharma environment
Robust track record of delivering projects into clinical trials
Experience successfully developing talent and forging strong partnerships across departments
Strong track record of publications and presentations and viewed as a scientific leader in the field
Strong people/team leadership and development experience PREFERRED QUALIFICATIONS
10+ years of industrial small molecule drug discovery experience
Strong working knowledge and track record of delivery in medicinal chemistry and drug discovery including delivery of candidates to Ph2 or beyond
Proven track record in establishment of project portfolios from idea-to-candidate
Experience successfully introducing and applying novel technologies to improve productivity in medicinal chemistry
Excellence delivering clear, strong IP strategies across a portfolio of projects
Strong working knowledge of all key Research and Development Lines
Extensive experience leading change and dealing with uncertainty Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Travel to Groton, CT site one (1) day/month
Occasional business travel is anticipated Work Location Assignment: On Premise The annual base salary for this position ranges from $185,800.00 to $309,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Research and Development #J-18808-Ljbffr

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