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ProBio proactively provides end-to-end CDMO service from drug discovery to commercialization with proactive strategies, professional solutions and efficient processes in cell and gene therapy (CGT), vaccine, biologics discovery and antibody protein drug to accelerate drug development for customers.
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GenScript's businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy.
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Serve as subject matter expert for residual DNA by qPCR, host cell protein ELISA, Residual Protein A ELISA, binding activity ELISA, Capillary Electrophoresis (CE), and capillary isoelectric focusing electrophoresis(cIEF), including qualification, assay validation and transfer activities.
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Recently, his research interests have been expanded to unconventional drug modalities, such as ADC, cyclic peptides, herbal medicines, covalent drugs, stable isotope labeled drugs, prodrugs, and protein therapeutics.
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PCO is looking for a Scientific Associate Director to join the Dev DMPK group that is an expert in ADME and pharmaceutical drug development of protein therapeutics and small molecule drugs. Within the Pharmaceutical Candidate Optimization (PCO) organization at BMS, the Development DMPK Team provides ADME (absorption, distribution, metabolism, and excretion) and PK (pharmacokinetics) support for all pipeline assets throughout clinical development, from candidate nomination through registration and lifecycle management.
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The primary purpose of this position is to lead and conduct laboratory experiments for the biophysical characterization of protein reagents for use across multiple technology platforms, including but not limited to: Flow cytometry, IHC, and immunoassays.
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In terms of viral vector service, \ProBio has a stable and high-yield viral vector platform. In terms of plasmid service, ProBio supports the most clinical approvals for CGT drugs including mRNA vaccines, CAR-T in China.
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Demonstrated experience developing and executing receptor binding assays, kinetics, and protein/RNA quantitation. In addition, hands-on experience with radioligand binding assays, protein (HTRF, BRET, luminescence, ALPHA technology, ELISA, western, etc.
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ProBio’s total cell and gene therapy solution covers CMC of plasmid and virus for IND filing as well as clinical manufacturing and commercial manufacturing. It is also the first GMP manufacturing platform to provide in vitro transcription (IVT) template linearized plasmids for mRNA vaccines and has supported several mRNA vaccine global enterprises to obtain clinical approvals.
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The lab has also developed community resources for the leading model alga Chlamydomonas, including a genome-wide mutant library and a systematic protein localization atlas. The lab has defined the pyrenoid's protein composition, discovered that it is a liquid-like organelle, characterized the structure and biogenesis of one of its three sub-compartments, the matrix, and developed a predictive model to guide its engineering.
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Experience with protein chemistry is a plus. Hands-on experience in HPLC and Mass Spectrometry instrument operation and maintenance. LC/MS bioanalysis assay development, optimization, validation, and execution supporting potential drug programs targeting the immune system.
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The Gene Development lab is the first stage in both our research-grade and GMP product development pipelines; The Molecular Biology Scientist’s responsibilities include all phases of new E.coli & Cell Culture product development from gene design and sub-cloning through protein expression testing and long term DN and cell-banking.
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Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis. We employ state of the art technologies, complemented by deep subject matter expertise and broad scientific knowledge, to deliver innovative and comprehensive preclinical in vitro datasets to support our drug discovery pipeline in disease areas such as cell therapy, oncology, immunology, fibrosis, neuroscience, and cardiovascular diseases.
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Perform QC biochemistry laboratory assay validation and transfer activities to support GMP manufacturing, testing and release of material, intermediates and finished products under FDA/EU regulations, applicable International Regulations, company processes and procedures.
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Create savory food product formulations, including meat protein applications to showcase dsm-firmenich flavors, ingredients, technologies, and innovations. Demonstrated working knowledge of ingredient functionality, food formulation, food process unit operations, and end-user foodservice operations; knowledge of meat processing a plus.
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protein job in Princeton, NJ
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