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This individual will provide strategic leadership and execution of clinical development plans that include characterization and prediction of the pharmacokinetics, pharmacodynamics, and drug metabolism of the drug candidate in selected preclinical and all clinical areas.
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Lead the design of medicinal chemistry efforts by applying in-depth knowledge of structure-activity relationships (SAR), a profound understanding of target biology, and predictive methods for assessing on- and off-target activity, physical properties, pharmacokinetics/pharmacodynamics (PK/PD), and synthetic feasibility.
$130ExpandUpdated 8 days ago - UpvoteDownvoteShare Job
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Advanced degree in medicinal chemistry, computational chemistry, computational biology, computational chemical biology, or a related field. We are a driving force behind drug discovery, and we are now eagerly searching for an exceptional computational scientist like you to join our ranks.
$174,400 - $261,600 a yearFull-timeExpandApply NowActive JobUpdated 1 month ago - UpvoteDownvoteShare Job
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You will be the drug metabolism and pharmacokinetics (DMPK) lead on project teams discovering and developing small molecule modulators of clinically meaningful targets. Work closely with DMPK CROs to design, coordinate, monitor and manage external ADME and PK studies.
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Strong background in quantitative and qualitative research methodologies related to systems biology, pharmacokinetics, and PK/PD. The qualified candidate will apply knowledge and technical expertise to characterize systems biology, pharmacokinetics, and pharmacodynamics-related aspects facilitating research efforts across a diverse portfolio of diseases and therapeutic approaches.
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Strong understanding of all aspects of compound optimization including synthetic chemistry, structure-based drug design, ligand-based drug design, pharmacokinetics, pharmacology, and toxicology.
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Working familiarity with analysis of research data, biostatistics, pharmacology and pharmacokinetics, international standards for Good Clinical Practice (GCP), clinical study design, ethics committee/Institutional Review Board review, preparation of manuscripts, abstract/posters, and oral presentations, overall drug/device clinical development.
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Senior Principal Scientist, Computational Medicinal Chemistry. Work at the intersection of experimental and groundbreaking digital technologies, with a particular emphasis on expertise in machine learning and artificial intelligence (AI) as applied to small molecule drug discovery.
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Working knowledge of biostatistics, regulatory, clinical pharmacology and pharmacokinetics. Working knowledge of biostatistics, regulatory, clinical pharmacology and pharmacokinetics. MD and/or PhD required, subspecialty training in neurology or gene therapy is preferred.
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Evaluates pharmacokinetics (drug effects) and assesses drug or nutrient interactions. Responsible for checking all medication and sterile products prior to dispensing and Pyxis refill deliveries.
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The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/DMPK, as well as translational PKPD Modeling & Simulation support to our portfolio. As the Director of DMPK, you will report to the Head of Boston DMPK and supervise ADME scientists locally in Boston who provide drug discovery and development support for our diverse portfolio including; small molecules, biologics, nano-medicines and PROTACs∯*∯ The qualified candidate will also work closely with our ADME team in Cambridge (UK.
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Our client offers preclinical services for drug discovery, focused on the use of nonhuman primates to determine pharmacokinetics, pharmacology and toxicology of small molecules and biologics. Our client offers preclinical services for drug discovery, focused on the use of nonhuman primates to determine pharmacokinetics, pharmacology and toxicology of small molecules and biologics.
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Apply expertise in drug metabolism and pharmacokinetics (DMPK) principles and translational QP and PKPD methodologies as studies move from preclinical to clinical phases. In this role the qualified candidate will act as a lead preclinical PKPD modeling expert in interdisciplinary teams to support the drug discovery and development process by applying his/her knowledge and technical expertise to quantitatively characterize the pharmacokinetics, pharmacodynamics, and biomarker (PK/PD/Biomarker) properties of drug candidates.
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Ph. D. with 10+ years of experience in pharmacokinetics, pharmaceutical sciences, or other related disciplines. Utilize preclinical ADME, pharmacology, and pharmacodynamic data to develop predictions for human efficacious dose.
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Solid understanding of drug development, clinical research, study design, pharmacokinetics, and medical terminology. In addition to its wholly owned clinical assets, Dragonfly has a deep pipeline of wholly owned preclinical candidates discovered using its proprietary platform, as well as productive collaborations with Merck, AbbVie, Gilead and Bristol Myers Squibb in a broad range of disease areas.
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pharmacokinetics job in Watertown, MA
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