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Support in vitro and in vivo validation of brain shuttles, using protein and cell binding assays, and in vivo brain and blood pharmacokinetics and pharmacodynamic (PK/PD) studies in mouse models.
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Works collaboratively with providers to provide guidance on appropriate use of medications, clinical pharmacology, pharmacokinetics, disease state management, and nutrition. Works collaboratively with providers to provide guidance on appropriate use of medications, clinical pharmacology, pharmacokinetics, disease state management, and nutrition.
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About the company:Our client offers preclinical services for drug discovery, focused on the use of nonhuman primates to determine pharmacokinetics, pharmacology and toxicology of small molecules and biologics.
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A demonstrable track record of leading, understanding and hands-on experience of drug metabolism and pharmacokinetics, both in vitro and in vivo studies, human PK prediction, DDI prediction and mechanistic understanding to support late-stage programs.
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Hands-on experience in population pharmacokinetics/pharmacodynamics, and other modeling and simulation approaches preferred (required for consideration at the Senior Director level) In-depth knowledge of drug metabolism, pharmacokinetics, biopharmaceutics, drug-drug interactions, and translational science.
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BS/BA degree in clinical pharmacology, pharmacokinetics, pharmacometrics, mathematics, engineering, computational biology or a related field required plus at least 14 years of relevant experience.
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Within the Pharmaceutical Candidate Optimization (PCO) organization at BMS, the Development DMPK Team provides ADME (absorption, distribution, metabolism, and excretion) and PK (pharmacokinetics) support for all pipeline assets throughout clinical development, from candidate nomination through registration and lifecycle management.
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Experience with a variety of data types and outputs, including clinical trial reports, pharmacokinetics/pharmacodynamics, patient-reported outcomes, data presentation, and interpretation. Experience with a variety of data types and outputs, including clinical trial reports, pharmacokinetics/pharmacodynamics, patient-reported outcomes, data presentation, and interpretation.
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Implementing multiple parameter optimization strategy to advance SAR by applying medicinal chemistry knowledge and understanding of ADME, pharmacokinetics, optimal physicochemical properties, and AI/ML prediction tools.
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MS/MA degree in clinical pharmacology, pharmacokinetics, pharmacometrics, mathematics, engineering, computational biology or a related field required plus at least 12 years of relevant experience.
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Ph. D. in pharmaceutics, pharmacokinetics, pharmacology, pharmacometrics, or related discipline, or Pharm. Supervise or plans, designs, executes and reports program-specific clinical pharmacology studies (e.g. assessment of QT, food effect, ADME, DDI strategy, special populations, etc.
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Lead a team of scientists and research associates to design and execute preclinical studies aimed at evaluating the pharmacokinetics, pharmacodynamics, efficacy, and safety of LNP-formulated drug candidates.
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Working knowledge of drug development, clinical research, study design, biostatistics, pharmacokinetics, the regulatory environment, and medical terminology. What you bring: 5+ years as a medical or scientific writer, or equivalent professional or educational experience (eg, graduate degree in life sciences.
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Evaluates pharmacokinetics (drug effects) and assesses drug or nutrient interactions. Responsible for checking all medication and sterile products prior to dispensing and Pyxis refill deliveries.
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Strong knowledge of pharmacokinetics and pharmacodynamics principles, immunogenicity, modelling and simulation, Model-Informed Drug Development, ADME Concepts, and regulatory clinical pharmacology requirements to support clinical development and regulatory submission.
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pharmacokinetics job in Cambridge, MA
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