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Job Description: As a Principal Scientist, Antibody Development, you will play a pivotal role in driving our antibody discovery programs from conception through to preclinical development.
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As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS. The candidate is expected to have strong collaborative skills to ensure robust partnerships with biologists, antibody discovery and engineering & bioanalytical scientists to advance ADC projects.
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As a Lab Technician, Bioanalytical, you will work with our Antibody Discovery Services team to support the discovery of antibody-based therapeutics. + You have a good understanding of antibody therapeutics.
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Your hands on experience with cell-based assays (e.g., cell-binding, proliferation, cytotoxicity, apoptosis, receptor activation, internalization, cytokine secretion, immune cell activity, gene expression response) for antibody and biologics screening and characterization (reporter cells, primary cells) using a variety of techniques (e.g., flow cytometry, luminescence, fluorescence, cell imaging) is needed.
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Perform animal tissue harvest, B cell separation, and refined enrichment techniques for antigen-specific antibody screening that will include plasma and memory B cell sorting (Beacon and FACS based methods.
$170,500 a yearFull-timeExpandUpdated Today - UpvoteDownvoteShare Job
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Validate antibody performance by WB, IHC, ICC, FC, and IP at QC stage for Reagent projects. Screen antibody candidates by sELISA, WB, IHC, ICC, FC, and IP at recombination stage according to the project requirement.
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Learn multiple antibody discovery platforms including B cell cloning, yeast display, and in vivo antibody discovery. Participate in the construction and screening of yeast display antibody libraries via flow cytometry.
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Strategically devise and implement in vitro antibody discovery approaches utilizing hands-on laboratory techniques, including both naïve and immune repertoires in yeast display platform. A good knowledge base in the field of n vitro based antibody discovery and engineering, specifically using a yeast display platform, as demonstrated by several years of hands-on technical know-how for multiple targets.
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Perform high-throughput screening (HTS) of antibody display outputs using ELISA and flow cytometry. Solid understanding of various antibody formats, including IgG, Fab, and single-domain antibodies, both in vitro and in vivo.
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The Senior Lab Automation Engineer will work closely with IPI’s researchers to update and implement automation solutions for a variety of experiments including transfections, protein and antibody purifications, yeast display campaigns, antibody characterization and method validation such as immunoprecipitation, immunofluorescence, immunohistochemistry, flow cytometry, ELISA, and other assay types.
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At least 10 (BS), 8 (MS), 0 (PhD) years’ experience in analytical development or quality control, mostly supporting antibody or ADC therapeutics under GMP. for antibody and ADC methods established at external laboratories for IPC, release, and stability testing.
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With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death.
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Do you have any antibody/molecular enzyme sales experience? Equipped with a comprehensive prokaryotic and eukaryotic protein expression system, a sophisticated mouse monoclonal antibody production system, and a trailblazing fourth-generation rabbit monoclonal antibody technology, our client stands at the forefront of in vitro diagnostic product development.
$90,000 a yearFull-timeExpandUpdated Today - UpvoteDownvoteShare Job
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Experience with multiple antibody discovery platforms including in vivo immunization and in vitro display approaches. Experience with in silico tools for developability screening, antibody engineering, LIMS.Excellent verbal and written communication and interpersonal skills for participating across functional groups and externally.
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The Scientist, Analytical Development & Quality Control is responsible for analytical development, feasibility, method qualification, routine, and stability testing of antibody drug conjugates and intermediates.
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antibody job in Cambridge, MA
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