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What You'll Do: Serve as the primary expert in the purification of sterile, injectable gene therapy materials, ensuring processes meet high standards of purity and quality. Substantial experience in developing purification processes for gene therapy or protein products, with proven success in scaling up processes for clinical manufacturing.
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Technical background knowledge in solid phase synthesis and related processes, relevant analytical, purification and downstream process techniques (oligonucleotides, and oligonucleotide-conjugates preferred.
Full-timeExpandApply NowActive JobUpdated 1 month ago - UpvoteDownvoteShare Job
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Knowledge of biologics downstream process development strategies (including inclusion body solubilization, refolding, column chromatography, conjugation, and formulation) and familiarity with best protein purification practices.
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The Scientist will regularly interface with Upstream (DNA Production), Downstream (Protein Purification), and Reg CMC colleagues, communicating data packages to ensure seamless coordination of activities.
Full-timeExpandApply NowActive JobUpdated 4 days ago - UpvoteDownvoteShare Job
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Have experience in basic molecular biology techniques (PCR, electrophoresis, nucleic acid or protein isolation and purification). o Sample prep for the extraction of biomolecules such as nucleic acids (DNA and RNA) and protein, downstream processing and analysis, using Covaris’ proprietary AFA™ technology.
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Upstream cell culture or downstream purification experience. Job Title: Process Engineer/Upstream or Downstream. Develop and maintain process control automation solution for bench top Finesse and DeltaV Controllers systems in Next Generation Lab.
ExpandApply NowActive JobUpdated 5 days ago - UpvoteDownvoteShare Job
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Serving as a technical/scientific Subject Matter Expert secondarily for downstream protein purification activities ranging from column chromatography, filtration (UF, DF, TFF), harvest and recovery.
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Director/Sr. Director - Process DevelopmentGreater Boston Area Competitive Compensation + excellent bonus/benefitsDuties and Responsibilities:Lead all process development activities (cell culture/banking/development, fermentation, protein purification, tech transfers)Oversee internal(in-house) and external vendors (domestic & international CDMOs)Work cross-functionally with CMC & Manufacturing leaders such as Analytical, Drug Product, QA/QC, Manufacturing, Supply Chain, etc.
$210,000 - $240,000 a yearExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Lead complex experiments for downstream process development, solving technical chromatography and purification challenges to achieve project goals. Principal RA/ Scientist Downstream Process Development.
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They will manage and mentor a team of purification scientists across 2 sites (Somerville and Andover, MA) that is responsible for performing protein purification and characterization at various scales across a range of different protein modalities stemming from upstream transient, bacterial, and stable cell systems.
Full-timeExpandApply NowActive JobUpdated 14 days ago - UpvoteDownvoteShare Job
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Instrumentation background, preventative maintenance, automation background (DeltaV or Finesse controllers), and process monitoring or trending experience. Initiating review and approval of changes to operating procedures and EHS change control process relating to the system.
$38 an hourExpandUpdated 14 days ago - UpvoteDownvoteShare Job
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Title: Process Development Engineer - Onsite. Chemical Engineering B.S preferred. Identify and implement engineering-based improvements or upgrades to process equipment, including identification of design requirements, options analysis, design, installation, startup and qualification of equipment.
$43 an hourExpandUpdated 14 days ago - UpvoteDownvoteShare Job
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Prime Medicine is seeking a co-op for the Spring 2025 semester with interest in large RNA molecules synthesis and downstream operations including purification t o join the Process Chemistry team.
Full-timeExpandApply NowActive JobUpdated 9 days ago - UpvoteDownvoteShare Job
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The ideal candidate will bring knowledge of mRNA translation, experience in next-generation sequencing and downstream analysis. Proficiency in RNA and DNA purification, qPCR and cloning.
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Five (MS level) or three (PhD. level) or more years of industry experience in downstream process development for large biomolecules, preferably mRNA and pDNA, with hands-on experience on a wide range of purification techniques for large nucleic acid molecules including affinity capture, ion exchange and hydrophobic interactions.
Full-timeExpandApply NowActive JobUpdated 13 days ago
downstream purification jobs in Boston, MA
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