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Downstream experience with standard chromatography and/or DNA purification kits is a plus. We are seeking motivated individuals with experience and familiarity with enzymatic synthesis, standard chromatography techniques, TFF, DNA purification kits, and molecular biology techniques such as DNA manipulations including PCR, ligations, restriction digestions, and plasmid cloning.
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Additional experience in downstream purification of biologics including chromatography separations and filtration operations (depth, dead-end, and ultrafiltration/diafiltration) is a plus.
$200,000 - $240,000 a yearFull-timeExpandApply NowActive JobUpdated Yesterday - UpvoteDownvoteShare Job
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Operate and maintain automated liquid handlers for plasmid purification, as well as downstream QC applications like NGS and DNA normalizations. Operate and maintain automated liquid handlers for plasmid purification, as well as downstream QC applications like NGS and DNA normalizations.
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As a Process Development Engineer/ Scientist in the Global Drug Substance Development group you will focus on CMC development, optimization and scale-up of mRNA synthesis and purification processes with the ultimate goal of transferring at scale methods to either the internal or external manufacturing team for GMP manufacturing of mRNA drug substance.
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Help develop scalable strategies for downstream product purification. Perform routine analytical and bioanalytical tasks such as HPLC, fragment analysis, UV, and fluorescence. FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.
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BioMedicine Design (BMD) is seeking a highly motivated Biochemist/Molecular Biologist to join Biotherapeutic Expression and Purification group (BEP) in Cambridge, MA. Qualified candidate will play an essential role in a high-energy DNA production and protein expression research laboratory.
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Develop phase-appropriate drug substance processes for antibodies and proteins, including cell banking, upstream cell culture, and downstream purification. 10+ years of experience in biologics process development with a strong understanding of antibody processing, including upstream and downstream processes.
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Director/Sr. Director - Process DevelopmentGreater Boston Area Competitive Compensation + excellent bonus/benefitsDuties and Responsibilities:Lead all process development activities (cell culture/banking/development, fermentation, protein purification, tech transfers)Oversee internal(in-house) and external vendors (domestic & international CDMOs)Work cross-functionally with CMC & Manufacturing leaders such as Analytical, Drug Product, QA/QC, Manufacturing, Supply Chain, etc.
$210,000 - $240,000 a yearExpandApply NowActive JobUpdated Today - UpvoteDownvoteShare Job
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Ideally experienced in 1 or more of the following: facilities and equipment startup, walk downs & troubleshooting, utilities (WFI, RO, HVAC) upstream, downstream, purification, recovery, building automation or other pharmaceutical manufacturing processes.
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Implement relevant purification protocols to ensure delivery of therapeutic oligonucleotides suitable for in vivo studies. The individual will execute relevant protocols to purify therapeutic oligonucleotides suitable for downstream in vivo studies.
Full-timeExpandApply NowActive JobUpdated 9 days ago - UpvoteDownvoteShare Job
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Develop and execute robust, scalable downstream processes for Dragonfly's novel multi-specific antibody and cytokine platforms ranging from purification, filtration, and analytical characterization.
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This position is a hands-on role, and the successful candidate will have deep knowledge and experience in long oligonucleotide purification and downstream processing to advance our cutting-edge gene editing drug discovery programs.
ExpandApply NowActive JobUpdated 6 days ago - UpvoteDownvoteShare Job
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These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. Synthesize and purify routine nucleic acid products for preclinical studies.
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The Research Production team is responsible for the upstream enzymatic synthesis and downstream manufacturing of drug substance to support pre-clinical trials. Directly assist in the planning and execution of laboratory experiments to develop manufacturing and purification of closed ended DNAs using the RES process.
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Sail Biomedicines is seeking a highly motivated and innovative Associate Director, Drug Substance Process Development to be the subject matter expert and leader of RNA manufacturing processes, including upstream and downstream activities.
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downstream purification jobs in Boston, MA
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