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Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Scientist, Antibody Discovery Platform Development located in Cambridge, MA.
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Hands on experience with antibody/protein characterization, antibody bioconjugation, purification, and characterization of conjugates. Perform biochemical and biophysical characterization of antibody ligands.
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10+ years experience in biologics process development and a strong working knowledge of antibody processing, including upstream and downstream processes. Dragonfly Therapeutics is a clinical-stage biopharmaceutical company committed to discovering, developing and commercializing therapies that use its novel multispecific antibody technology to harness the body's immune system to bring breakthrough treatments to patients.
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Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RN, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.
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You have experience working with and developing assays (keywords include: lateral flow assays (LFA), immunoassays, ELISA, In Vitro Diagnostics (IVD), point-of-care diagnostics, rapid diagnostic tests, paper-based sensors, biosensors, microfluidic, bioconjugation, nanoparticle conjugation, antibody purification.
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Extensive working knowledge of biomarker and bioanalytical assay development and cutting-edge Omics methodologies in the clinic. Successfully manage CROs and establish relationships to develop biomarker assays, monitor assay qualification/validation at CROs, as well as bioanalytical/biomarker testing in the clinical trials.
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Fundamental understanding of antibody and molecular enzyme products is required. Knowledge of antibody, and/or molecular enzyme sales is a must. ABclonal has a comprehensive prokaryotic and eukaryotic protein expression system, advanced mouse monoclonal antibody production system and a fourth-generation rabbit monoclonal antibody technology.
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With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death.
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Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RN, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immune mediated diseases, among others.
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We are seeking a talented and motivated student to be part of the Antibody Discovery Research within the Immunology, Infectious Disease Department. Provide scientific and technical support for multidisciplinary project team, with a focus on immunological assays including, but not limited to, ELISA, Luminex, Octet, flow cytometry, cell culture, etc.
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Experience in pooled or arrayed high throughput screening pipelines, immunology, immunotherapy, antibody discovery/development, gene engineering, genomics, computational biology, or synthetic biology preferred.
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Develop and perform immunological assays, including ELISAs, ELISpots, flow cytometry, and fluorescence activated cell sorting, with a special focus on development of high-throughput measures of antibody function.
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Essential for the rolePh. D. in Biotechnology, Molecular Biology, Biochemistry or other relevant scientific field with 5+ years of experience in antibody engineering and/or bispecific design. You will play a significant role in designing future modifications to integrated robotic and liquid handling systems; ensuring world class precision and execution of high throughput expression & purification of antibody therapeutics on a microgram-to-milligram scale and be an advocate for utilizing various automation platforms.
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A minimum of 10 years of experience in clinical pharmacology within the pharmaceutical or biotechnology industry, with significant experience in antibody development. The Senior Director of Clinical Pharmacology will play a pivotal role in leading our clinical pharmacology efforts to advance the development of our cutting-edge antibody portfolio.
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Screens approximately 1000 potential recipients monthly for anti-HLA antibody determination, against a panel of soluble HLA on microbeads and/or a 50 member frozen cell panel. Performs appropriate absorptions with platelets and autologous cells to further characterize antibody present in patient sera.
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antibody job in Boston, MA
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