Bio Instrumentation Engineer For Hardware, Software, and Computational Biology

About the CompanyOvelle is revolutionizing fertility treatment through human in vitro oogenesis—producing eggs from somatic cells. We have developed technology to create the cell types of the ovary from human induced pluripotent stem cells (iPSCs) by manipulating expression of transcription factors and RNA-binding proteins. Notably, we are the first company to produce meiotic oogonia-like cells from human iPSCs. This is an important step towards in vitro oogenesis because activating meiosis has been a key challenge in the field. We will incorporate these meiotic oogonia-like cells into ovarian organoids to create synthetic ovaries capable of producing eggs. By innovating egg production, we aim to make fertility treatments more accessible and affordable. If we are successful, it will mark a paradigm shift in treatments for infertility, and offer a new path to parenthood for millions of people around the world. Come help us build an exciting future all of us want to live in.About the Specific RoleWe seek a Bio Instrumentation Engineer to build the custom hardware, software, and computational pipelines that will accelerate our path to in vitro oogenesis. This role sits at the intersection of microfluidics, microscopy, lab automation, and computational biology. You will design devices to culture, and image our cells and organoids; develop the quantitative image analysis and bioinformatics pipelines that turn raw data into insight; and help us with lab automations. This is an opportunity for an elite hardware hacker who is equally at home developing devices as they are writing code to analyze single-cell sequencing data.How You Will ContributeDesign, fabricate, and characterize custom devices for culturing, and imaging cells, organoids, and other biological samplesBuild and optimize custom imaging setups and protocols—confocal, fluorescence, and live-cell—and integrate them with automated stages, pressure sources, liquid handling, and environmental controlsDevelop quantitative image analysis pipelines for extracting features such as nuclear localization, protein gradients, morphology, and division dynamics from confocal and fluorescent microscopy datasetsAnalyze single-cell RNA sequencing (scRNA-seq) and DNA methylation datasets to characterize cell identity, lineage trajectories, and epigenetic state across our iPSC-derived cell typesBuild software and firmware that glue hardware together—interfacing microscopes, liquid handlers, incubators, microcontrollers, and custom-built rigs—to automate repetitive or high-throughput wet-lab workflowsPartner closely with wet-lab biologists to translate experimental needs into instrumentation and analysis tools, and ship production-ready, reproducible pipelinesDocument, version, and share devices, schematics, firmware, and code with the rest of the teamQualificationsStrong fluency with confocal and fluorescence microscopy, and with quantitative image analysisProficiency in bioinformatics analysis of single-cell data, including scRNA-seq and DNA methylation dataA track record of building or hacking lab hardware—microcontrollers, 3D printing, CAD, motion control, pneumatic or pressure systems, sensor integration, or similar—to automate experimental workflowsStrong analytical and problem-solving skills, with the ability to design, debug, and iterate on complex multi-step hardware–software–wet-lab systemsNo specific degree required. We care about what you can build and what you know: if you’re genuinely excellent at this work, we want to talk to youOvelle is a research-first startup where scientists work together on only one deep and important problem: IVG. We operate like a fast, efficient academic lab without constraints. We’re committed to sharing our work with the scientific community and welcome collaborations with academic researchers. We are well funded and have future funding commitments. Our people are the heart of our success and our compensation and benefits reflect this. Our culture blends a commitment to rapid innovation with the belief that offering great benefits and perks directly supports scientific progress. We urge everyone to apply as we believe in encouraging inclusion, acceptance, and understanding by employing individuals who bring unique perspectives to the company.Our benefits5 paid holidays20 days PTOUp to 12 weeks paid leave for new parents who are primary caregiversPerq MBTA pass programMedical, Dental, and VisionMatching 401(k) plan after first yearTuition reimbursement for work-related continuing education