Principal Scientist, Analytical Development, Oligo and Small Molecule

Principal Scientist, Analytical Development, Oligo and Small Molecule United States - RemoteThis position may be performed remotely, but requires the flexibility and willingness to travel as needed.Position SummaryThe Principal Scientist, Analytical Development will play a critical role in advancing Praxis' clinical and commercial pipeline by translating analytical strategies from development into manufacturing across our virtual network of CMOs and external partners.This role is particularly focused on advancing oligonucleotide-based therapeutics, while also supporting small molecule programs across the portfolio. The individual will bring deep expertise in analytical method development, qualification, validation, troubleshooting, and GMP testing for oligonucleotide drug substances and drug products, with the ability to apply phase-appropriate analytical strategies across multiple modalities.This is a highly cross-functional, hands-on leadership role requiring close partnership with Drug Substance, Drug Product, Quality, Regulatory, and Manufacturing teams to ensure robust, scalable, and compliant analytical control strategies. The successful candidate will help shape an agile, forward-looking analytical development function capable of supporting innovative CNS therapies from early development through commercialization.Primary ResponsibilitiesServe as Analytical Lead across CMC programs, with primary responsibility for oligonucleotide analytical development activities and support for small molecule programsLead analytical method development, qualification, validation, transfer, and GMP testing activities across internal teams and external partnersDrive technical troubleshooting, data interpretation, method lifecycle management, and review of analytical documentation including validation reports, stability reports, specifications, and CoAsDesign and implement phase-appropriate analytical control strategies, specifications, and stability programs for oligonucleotide and small molecule drug substances and drug productsDirect and manage CRO/CMO analytical partners to ensure high-quality execution, strong communication, and continuous operational improvementCollaborate cross-functionally to strengthen CMC operations, improve processes, and establish scalable technical and business practices across the analytical functionContribute strategic and technical expertise to support regulatory filings, commercialization readiness, and ongoing product lifecycle managementQualifications and Key Success FactorsQualificationsAdvanced degree (PhD preferred; Master's with significant industry experience considered) in Analytical Chemistry or related discipline with 5–7+ years of industry experienceStrong industry experience in analytical development for oligonucleotide drug substances and/or drug products requiredExperience supporting small molecule drug substances and solid oral dosage forms strongly preferredDeep knowledge of analytical techniques relevant to oligonucleotides, including impurity characterization, stability assessment, and GMP control strategiesStrong understanding of US and EU cGMP requirements and analytical best practices for drug substance and drug product developmentExperience supporting CMC development across multiple stages of development, including regulatory submissions, validation, and commercialization activitiesExperience managing external CRO/CMO analytical networks and building productive technical partnershipsStrong working knowledge of quality systems, reference standards, stability programs, and compendial testing requirementsKey Success FactorsBrings deep technical curiosity and strong scientific judgment, particularly in emerging oligonucleotide modalitiesOperates with high ownership and accountability in fast-moving, ambiguous environmentsBalances strategic thinking with hands-on execution and problem solvingCommunicates clearly and collaborates effectively across functions and external partnersContinuously challenges assumptions and looks for smarter, more scalable ways of workingThrives in agile environments that require adaptability, rigor, and urgencyHighly organized, detail-oriented, and motivated by delivering high-quality outcomes that advance therapies for patientsCompensation & BenefitsAt Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let's achieve the impossible together!To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below. Final salary range may be modified commensurate with job level, education, and experience.Annualized Base Salary$165,000 - $185,000 USDCompany OverviewPraxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws. Attention: Job Scam Alert Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com . Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.