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FibroGen recently expanded its research and development portfolio to include antibody-drug conjugate (ADC) and immuno-oncology product candidates for the treatment of solid tumors. Pamrevlumab, an anti-CTGF fully human monoclonal antibody, is in clinical development for the treatment of metastatic pancreatic cancer and locally advanced unresectable pancreatic cancer (LAPC.
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ResponsibilitiesExtract protein, DNA and/or RNA from necropsied animal tissueRun ddPCR, qPCR, ELISA, Western Blot etc analysis on tissue extractsCell culture, Neutralizing antibody assays and total antibody assaysSample analysis assay optimizationSOP writingData recording and analysisQC analysis This position directly impacts preclinical outcomes including proof of concept, ED50, MED, clinical hold response and IND enabling studies.
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Proficiency in multi-parameter flow and/or spectral cytometry including panel design, sample preparation and acquisition, antibody titration and data analysis. Experience in molecular and cellular biology techniques, including but not limited to ELISA based assays, Proquantum, Luminex and ddPCR.
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This role will support chromatography assay development for monoclonal antibodies, bispecific antibodies, cytokines, and antibody drug conjugates. This role will support chromatography assay development for monoclonal antibodies, bispecific antibodies, cytokines, and antibody drug conjugates.
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Reporting to the Oncology Discovery Therapeutic Area head, you will partner with data science and machine learning (DSML), translational oncology and computational biology colleagues to gain deep insights into the biology and efficacy of antibody drug conjugates (ADCs) with the goal of delivering therapeutics to the right patients.
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CytomX has a broad pipeline, which comprises seven therapeutic candidates across multiple treatment modalities including antibody-drug conjugates ("ADCs"), T-cell engaging bispecific antibodies ("TCBs"), and immune modulators such as cytokines and checkpoint inhibitors ("CPIs.
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Design, develop, and optimize cell-based functional assays utilizing a variety of techniques including flow cytometry, ELISA, and other molecular and cellular biology methods to assess antibody binding, kinetics, stability, and target engagement to support and scale up BigHat’s discovery efforts.
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The PMV organization provides innovative technologies and strategic support for development and commercialization of Genentech and Roche’s biologic portfolio, including standard monoclonal antibodies as well as complex immunoglobulin constructs, fusion proteins, and modified proteins such as antibody drug conjugates.
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Familiarity with synthetic biology and sequencing products and processes, drug development landscape, antibody therapies, and personalized medicine,. Familiarity with synthetic biology and sequencing products and processes, drug development landscape, antibody therapies, and personalized medicine.
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Vir Biotechnology (Vir) is seeking a Summer Research Associate reporting to a Scientist II, Analytical Development Bioassays to lead development of bioassays to interrogate the mechanism of action for antibody and other biologic therapeutics.
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Lead preclinical validation of prioritized ADC antibody-linker-warhead combinations in cells and tumor models. Lead preclinical validation of prioritized ADC antibody-linker-warhead combinations in cells and tumor models.
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Extensive experience with formulation development and tox/clinical in-use evaluation for monoclonal antibodies, bispecifics, antibody-drug conjugates, fusion proteins, and other complex biologics formats, in a wide concentration range from ultra low to high; experience of IND and/or BLA filings.
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In this vital role you will be responsible for the development and implementation of the Quantitative Clinical Pharmacology, Modeling and Simulation strategies for cutting-edge novel modalities including Bi-specific T-cell engagers, Bi-specific antibodies, oncolytic viruses, antibody-drug-conjugates, CAR-T cells-based therapies in addition to small molecule & mono-clonal antibodies.
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Vera is also developing MAU868, a monoclonal antibody designed to neutralize infection with BK Virus, a polyomavirus that can have devastating consequences in certain settings such as kidney transplant.
$202,000 - $226,000 a yearFull-timeExpandApply NowActive JobUpdated 4 days ago - UpvoteDownvoteShare Job
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Vera's lead product candidate is atacicept, a fusion protein self-administered as a subcutaneous injection once weekly that blocks both B lymphocyte stimulator (BLyS) and a proliferation inducing ligand (APRIL), which stimulate B cells and plasma cells to produce autoantibodies contributing to certain autoimmune diseases, including IgA nephropathy (IgAN), also known as Berger's disease and lupus nephritis.
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antibody job in South San Francisco, CA
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