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Bachelors or masters graduate with 1-3 years of experience in immortalized or primary cell culture, ELISA, and in-vitro assays. The Investigative Toxicology group's goal is to use ex vivo and in vitro tools to assess safety liabilities and mechanisms of toxicity observed pre-clinically to support the entire portfolio spanning discovery through development.
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Direct experience performing in vitro functional assays is preferred, including cytotoxicity, proliferation, multi-color flow cytometry and cytokine release. Execute in vitro and in vivo studies to support IND-enabling data packages.
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The successful applicant will execute a broad research program focused on growing stem cell technology in the Vedantham Lab and will include probing specific developmental pathways in vitro using the hiPSC differentiation system, CRISPR screening of hiPSC-derived cardiomyocytes, application of standard molecular biology techniques and next generation sequencing (scRNseq, scATAC-seq, ChIP-Seq), and may eventually involve tissue engineering.
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Contributing to the design, implementation, and interpretation of in vivo and in vitro experimental studies. Prior experience with bioanalytical or biomarker assay development strongly preferred.
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Reporting to the VP, Disease Biology & Translational Science, this individual will be responsible for helping to establish and expand the company's capabilities for preclinical in vitro and clinical ex vivo disease pathobiology establishing in vitro/ex vivo models to interrogate complex disease models to rank and screen our therapeutic candidates and establish the drug's mechanism of action for multiple indications.
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Strong hands-on experience in designing and executing in vitro and in vivo studies to validate targets and treatment ideas using ADCs, mAbs, or other targeted therapies. Establish strong in-house capabilities to perform in vitro experiments with high throughput and characterize the MoA of innovative payloads.
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In addition to assay development and fit for purpose mechanistic studies, this role focuses on the application of novel methodologies to the in vitro and ex vivo studies conducted by Safety Assessment as well as support for routine toxicology assay screening for drug discovery programs.
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Demonstrated experience of 3-5 years in executing a variety of cell biology techniques, including mammalian cell culture, in vitro cellular assays (e.g., cell viability, proliferation, invasion, apoptosis), and luciferase assay.
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Manage and process compound requests to support drug discovery, including sorting and plating liquid samples for in vitro assays and preparing samples for storage and shipment. Hand-on experience with Beckman Access robotic system and Hamilton Verso automated sample store.
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We strive to dissect the molecular, cellular, and tissue-level mechanisms by which genetic variants modulate disease risk, with a major focus on the role of microglial cell function in vitro and in vivo.
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Investigative Toxicology groups goal is to use ex vivo and in vitro tools to assess safety liabilities and mechanisms of toxicity observed pre-clinically to support the entire portfolio spanning discovery through development.
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Responsibilities:We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays.
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They will also contribute to ongoing efforts to understand the impact of complex-in-vitro models in hazard id and liability assessment. Experience with complex in-vitro model systems is highly desired.
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We are seeking a highly motivated Senior Principal Scientist/Associate Director specialized in characterizing the in vitro and in vivo ADME/PK properties of small molecule lead compounds and drug candidates.
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The candidate should have experience performing cellular immunological techniques, including in vitro immune cell assays, multi-color flow cytometry, and ELISA/MSD/Luminex utilizing primary immune cells.
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vitro job in San Francisco, CA
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