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The successful candidate will work collaboratively with Translational Genetics and Discovery Chemistry to identify new therapeutic areas for application of the TRiM platform technology and develop appropriate in vitro and in vivo models for proof of concept studies and drug discovery activities.
$215,000 - $270,000Full-timeExpandApply NowActive JobUpdated 1 month ago - UpvoteDownvoteShare Job
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Principal Scientist, Peptide Protein Chemistry. Proficient in all aspects of modern peptide synthesis, protein bioconjugation, peptide and protein purification and analysis.
Full-timeExpandApply NowActive JobUpdated 3 months ago - UpvoteDownvoteShare Job
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Our department is part of the highly multidisciplinary Applied Biosciences and Engineering Group, comprised of researchers with expertise in many disciplines of biology (molecular biology, microbiology, virology, immunology, and biochemistry), chemistry (analytical, organic, and physical), computational science (bioinformatics, machine learning, computational chemistry), and engineering (chemical, mechanical, and biomedical.
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Responsibilities Representative responsibilities will include, but not necessarily be limited to, the following: Collaborate with research, analytical development and process development teams to develop, qualify/validate AAV gene therapy cell-based biological potency assays, protein chemistry assays, and molecular biology assays for process monitoring and drug product release, specifically SDS-PAGE, western blot, droplet digital PCR or qPCR, culture of primary mammalian cells, and cell.
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Knowledge of gene editing and analytical chemistry (e.g., GC, HPLC) is favorable, along with a background in protein interaction assays. Knowledge of gene editing and analytical chemistry (e.g., GC, HPLC) is favorable, along with a background in protein interaction assays.
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Collaborate closely with multiple teams, including Bioinformatics, Protein Engineering, Systems Integration, and Surface Chemistry. Senior Scientist is Ph. D. in Biology, Genetics, Bioengineering, Chemistry, Chemical Engineering, or a related field, with at least 5 years of relevant industry experience (may include postdoc work.
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Execution and understanding of protocols for protein chemistry and target validation, such as SDS-PAGE, ELISA, western blots. Apply molecular and cell-based assays including but not limited to RNA transfection, RNA & protein isolation, gene expression analysis (RT-qPCR & RNA Sequencing), western blot, and fluorescence immunocytochemistry.
$85,000 - $105,000 a yearFull-timeExpandUpdated Yesterday - UpvoteDownvoteShare Job
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Experience in optimizing and delivering peptide-protein conjugates as candidates for clinical trial. Strong understanding of peptide and protein structure and associated biophysical techniques to assess structure, stability and behavior in solution.
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Must have a high level of technical knowledge and skills in a broad range of biochemistry and/or enzymology-related fields including biochemical pathways, protein engineering, enzyme mechanism/kinetics, complex assay development, and protein expression, purification, and characterization.
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Contribute to the overall scientific and discovery strategy for the CT SD site in close collaboration with functional leaders such as in vivo pharmacology, data science, protein sciences, medicinal chemistry and translational oncology to ensure that we are delivering on our strategy, taking data driven go/no go decisions and resourcing and prioritizing programs accordingly.
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Utilize extensive knowledge of polymer chemistry principles for materials selection/management, formulation processes to enhance the scalability and quality of the lens material. Background in organic-polymer synthesis and characterization, biocompatible polymers, peptides and lipid-protein-conjugates, oligonucleotides, structure-property relationships, formulation and process development, small & large molecules, analytical separations, isolation and identification of impurities.
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Experience with ADME assays (microsome and hepatocyte metabolism, transporters, absorption, protein binding, CYP450 substrate and inhibition assays) a plus. B.S. or M.S. in in Bioanalytical Chemistry, Pharmaceutical Sciences, Drug Metabolism or other relevant life science field, or equivalent education and experience.
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This position will be part of a highly matrixed, cross-functional discovery team with opportunities to interact across protein engineering, plant pathology and analytical chemistry functional teams.
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Serve as subject matter expert for enzymology, protein biochemistry, protein expression and purification, and enzyme engineering. The advanced bio & physical sciences for low carbon energy (AB&PS) team is the central research organisation for biosciences, chemistry, materials sciences, fundamental biofuels pathways, green hydrogen/ electrochemistry, and the science of carbon capture and the bp Biosciences Center (BSC) in San Diego, Ca, is one of bp’s global research hubs.
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Under supervision of the Research Director, incumbent will perform a variety of laboratory procedures involving protein chemistry and molecular biology. Under supervision of the Research Director, incumbent will perform a variety of laboratory procedures involving protein chemistry and molecular biology.
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protein chemistry jobs in San Diego, CA
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