Sr. Research Associate - Purification Process Development

Position SummaryWe are seeking a highly motivated Protein Purification Process Development Scientist with strong expertise in downstream processing of biologics. The ideal candidate will have hands-on experience in protein purification, process characterization, and scale-up activities, with a particular focus on antibody-based products and conjugation workflows. This role will contribute to developing robust, scalable purification processes from bench to manufacturing scale.Key ResponsibilitiesDesign, develop, and optimize protein purification processes for biologics, including monoclonal antibodies and antibody-drug conjugates (ADCs).Execute and troubleshoot purification workflows using chromatography systems (AKTA), filtration, and centrifugation techniques.Lead process development activities including:Bench-scale development and optimizationScale-up (bench to pilot and manufacturing scale)Scale-down model developmentPerform process characterization studies to assess robustness, scalability, and critical process parameters (CPPs).Develop and optimize conjugation processes for antibody-drug conjugates.Implement and optimize tangential flow filtration (TFF) and ultrafiltration/diafiltration (UF/DF) operations.Conduct harvest clarification using centrifugation and depth filtration methods.Analyze data, interpret results, and prepare technical reports and documentation.Collaborate cross-functionally with upstream development, analytical, and manufacturing teams.Support technology transfer activities and process validation efforts.Ensure compliance with regulatory guidelines and internal quality standards.Required QualificationsBachelor’s, or Master’s in Chemical Engineering, Biochemical Engineering, Biochemistry, Chemistry, or a related scientific discipline.2+ years of proven experience in protein purification process development and process characterization.Hands-on expertise in:Chromatography systems (AKTA)Tangential Flow Filtration (TFF) and Ultrafiltration/Diafiltration (UF/DF)Filtration and centrifugation techniquesExperience with biologics purification, particularly monoclonal antibodies and antibody-drug conjugation.Strong understanding of scale-up principles (bench-to-pilot and bench-to-manufacturing).Experience developing scale-down models and assessing process robustness.Preferred QualificationsPrior experience working on antibody-drug conjugates (ADC) and conjugation chemistries.Knowledge of regulatory expectations for biologics process development.Familiarity with GMP environments and technology transfer to manufacturing.Strong problem-solving, data analysis, and documentation skills.