Manager, Genetic Product Quality (Fully Remote) - Variant Interpretation

Manager, Genetic Product Quality (Variant Interpretation) — RemoteRemotePosition OverviewWe are seeking a Manager, Product Quality (Variant Interpretation) to lead the scientific rigor, consistency, and scalability of our variant interpretation efforts. This is a high-impact leadership role responsible for ensuring the accuracy and defensibility of data that powers our products, supports clinical decision-making, and informs pharmaceutical research. As curation volume, product complexity, and client engagements grow, this role will serve as the scientific authority for complex variant interpretation while building and leading a high-performing QA function. You will shape how interpretation is done at scale—driving standards, improving systems, and mentoring a team of scientists.If you are passionate about genomics, thrive in complex scientific problem-solving, and want to influence both product and patient impact, this is an opportunity to lead from the front.Position ResponsibilitiesVariant Interpretation & Scientific LeadershipServe as the final scientific authority for complex or ambiguous variant interpretation cases, including conflicting clinical and functional evidenceApply deep expertise in ACMG/AMP guidelines to ensure accurate and defensible classificationsLeverage clinical experience to contextualize variant interpretations and ensure clinical relevance and applicabilityGuide evaluation of functional studies and literature to support high-confidence interpretation decisionsSupport high-impact client deliverables, including clinical and pharmaceutical use casesGermline experience preferredQuality Assurance & Standards OwnershipOwn QA/QC standards across all variant interpretation workflowsEnsure consistent application of internal frameworks, nomenclature standards (HGVS), and interpretation criteriaOversee external data quality, including ClinVar submissions and discrepancy resolutionManage, mentor, and develop a team of QA scientists and curatorsProvide coaching on interpretation, evidence evaluation, and best practicesSet clear performance expectations and maintain accountability for quality standardsProcess Improvement & ScalabilityDesign, implement, and continuously improve SOPs, QA processes, and workflowsIdentify systemic quality issues and lead solutions that scale across teams and projectsBalance standardization with flexibility to meet diverse client and product needsCross-Functional CollaborationPartner with product, engineering, and leadership to improve tools, workflows, and data qualityContribute to broader data and product strategy through scientific expertiseAbout YouYou are a highly experienced variant interpretation expert who combines scientific depth with leadership capability. You're comfortable making high-stakes decisions in ambiguous situations, and you take ownership of quality, not just your work, but the work of the team.You bring a strong QA mindset, a bias toward evidence-based decision-making, and a drive to improve systems.Required Skills & Experience5+ years of hands-on variant interpretation experience in a clinical or equivalent settingAdvanced degree (PhD, MS in Genetics/Genomics) or Genetic Counselor (CGC)Deep expertise applying ACMG/AMP guidelines in complex scenariosStrong experience evaluating clinical and functional evidence from scientific literatureProficiency in HGVS nomenclature, including normalization and variant disambiguationDemonstrated ability to make independent, high-confidence scientific decisionsPreferred / Nice to HaveExperience with ClinVar submissions and resolving interpretation discrepanciesPrior people management or strong leadership experienceExposure to a broad range of disease areas or gene classesWhat You'll BringStrong scientific judgment, especially in ambiguous or conflicting evidence scenariosA rigorous QA mindset with exceptional attention to detailAbility to mentor and elevate othersProcess-oriented thinking with a focus on scalabilityClear, structured communication of complex scientific conceptsOwnership mentality for quality, team performance, and outcomesWhy Join GenomenonOwn Scientific Quality at Scale: Shape how variant interpretation is performed across products, clients, and public data resources.Lead and Build: Develop a high-performing team and establish systems that scale with the organization.Make a Real Impact: Your work directly supports clinical decisions, patient outcomes, and pharmaceutical research.Tackle Meaningful Complexity: Work on challenging, high-impact problems at the intersection of genomics, data, and real-world application.J-18808-Ljbffr