Germany – Postdoc in Genomic Instability and Neurodegeneration at German Center for Neurodegenerative Diseases

University: German Center for Neurodegenerative DiseasesCountry: GermanyDeadline: Not specifiedFields: Neuroscience, Molecular Biology, Genetics, Biomedical Sciences, BioinformaticsAre you passionate about advancing our understanding of neurodegenerative diseases and eager to translate laboratory discoveries into real-world therapies? If you are driven by the challenge of unraveling the cellular mechanisms underlying ALS and FTD, this postdoctoral opportunity at the German Center for Neurodegenerative Diseases (DZNE) in Munich could be the next significant step in your scientific career.About The University Or Research InstituteThe German Center for Neurodegenerative Diseases (DZNE) is recognized as a world-leading, internationally oriented research institution dedicated to investigating diseases of the nervous system. With multiple sites across Germany, DZNE fosters a collaborative and interdisciplinary environment that brings together top-tier scientists from diverse backgrounds. Its Munich branch, where this position is based, is at the forefront of innovative research in neurobiology and translational medicine. Germany itself is renowned for its investment in science and technology, offering a vibrant academic culture, excellent infrastructure, and a high quality of life. Researchers benefit from a supportive atmosphere, a strong tradition of scientific excellence, and access to cutting-edge resources and facilities.Research Topic and SignificanceThe focus of this postdoctoral project is to explore the genomic instability associated with the (G4C2)n repeat expansion in the C9orf72 gene—a major genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research is part of the ERC Advanced Grant-funded epiC9repair project, which aims to decode how aberrant DNA repair and genomic instability contribute to C9orf72 pathogenesis. By leveraging advanced genomic, epigenomic, and genome-editing tools, the project seeks to identify new therapeutic targets and biomarkers that could fundamentally alter the diagnosis and treatment of neurodegenerative diseases. Understanding these mechanisms is not only crucial for scientific progress but also has significant societal impact, given the increasing prevalence of neurodegenerative disorders in aging populations worldwide.Project DetailsAlso SeeGermany – PhD in Resilience Research at LMU University Hospital MunichCanada – PhD and Postdoc Positions in Neuroscience at University of ManitobaGermany – PhD & Postdoc in Applied and Numerical Analysis at Technical University of MunichGermany – Fully Funded PhD in Ageing Research at University of CologneSwitzerland – PhD in Gastroenterology at University of BaselThe Successful Candidate Will Join The Laboratory Of Prof. Dr. Dieter Edbauer At DZNE Munich. The Lab Is Renowned For Its Pioneering Work In ALS And FTD, Employing a Multidisciplinary Approach That Integrates Epigenomics, Genome Editing, IPSC-derived Neurons, And In Vivo Models. The EpiC9repair Project Offers The Unique Opportunity To– Design advanced CRISPR screens and develop innovative chromatin mapping techniques in iPSC-derived neurons to characterize and modulate DNA repair and epigenetic changes at the repeat locus.– Identify epigenetic biomarkers that correlate with disease progression and regional neurodegeneration in patient samples using techniques such as ChIP-seq, ATAC-seq, or long-read sequencing.– Translate these discoveries into therapeutic interventions using AAV and ASO technologies in mouse models.The lab’s research environment is highly collaborative and supportive, with a strong emphasis on translational potential and publication in high-impact journals. The position is initially limited to two years, with the possibility of extension depending on performance and funding.Candidate ProfileThe Ideal Applicant Will Possess The Following Qualifications– A PhD in neuroscience, molecular biology, or a related field.– A first-author publication in a respected scientific journal.– Demonstrated intellectual independence, technical versatility, and a genuine passion for deep scientific inquiry.– Experience with iPSC-derived human neurons and/or transgenic mouse models.– Proficiency with next-generation sequencing and data analysis (e.g., RNA-seq, ChIP-seq, long-read sequencing, multiomics analysis) and coding skills in R or Python.– A proactive, collaborative mindset and excellent communication skills in English.Successful candidates will be motivated, curious, and eager to contribute to high-impact, interdisciplinary research with real translational potential.Application ProcessInterested applicants should submit the following documents in a single PDF file:– Cover letter (detailing motivation, alignment with the lab’s research, and relevant experience)– Curriculum Vitae– Academic transcriptsThe review of applications will begin immediately and continue until the position is filled.Apply here: https://jobs.dzne.de/de/jobs/101510/postdoctoral-opportunity-fmx-exploring-genomic-instability-in-c9orf72-alsftd-146420258ConclusionThis postdoctoral position at the German Center for Neurodegenerative Diseases offers a unique opportunity to advance your research profile in a world-class environment while making meaningful contributions to the fight against neurodegenerative diseases. If you are passionate about neuroscience, genetics, and translational research, and eager to work at the interface of basic science and therapeutic development, you are strongly encouraged to apply. For more opportunities like this, follow the links below and stay updated on the latest academic positions.Main Category: life & medical sciencesUniversity: German Center for Neurodegenerative DiseasesReal Country: GermanyWant to calculate your PhD admission chances? Try it here:https://phdfinder.com/phd_admission_chance_calculator/ Get the latest openings in your field and preferred country—straight to your email inbox. Sign up now for 14 days free: https://phdfinder.com/position-alert-service/We’re an independent team helping students find opportunities.Found this opportunity helpful? Support us with a coffee!