Scientist, Analytical Development and Quality Control

CompanyNurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.Position Nurix Therapeutics seeks an experienced Scientist to join the Analytical Development and Quality Control group. The Scientist will conduct analytical method development and material characterization studies to inform drug substance and drug product development. They will also provide operational oversight at external CDMO/CTL partners, manage reference standards and impurity markers, collaborate in CMC risk management, and author technical reports.In Nurix’s laboratories, the Scientist will characterize material attributes and impurities by high resolution mass spectrometric and multidimensional chromatographic techniques. They will determine impurity structures, characterize material stability, and elucidate mechanisms of degradation. They will employ state of the art QbD approaches to develop and troubleshoot chromatographic test methods to accelerate and derisk QC activities performed externally at CDMOs and CTLs. The Scientist will critically evaluate characterization data and communicate results in multidisciplinary teams.The ideal candidate must have demonstrated expertise in mass spectrometry and hands-on experience with liquid chromatography. Hands-on experience with two-dimensional liquid chromatography is a plus.This position is onsite at Nurix headquarters in Brisbane, CA.Key ResponsibilitiesCharacterization and development studies at our internal laboratory:2D-LC for impurity profiling of complex samples, derisking HPLC test procedures, and adaptation of incompatible methods to mass spectrometryStructural elucidation by high resolution Orbitrap Tribrid Mass SpectrometryQbD HPLC method development using multivariate DOE softwareForced degradation and elucidation of degradation mechanismsAccelerated predictive stability studies and modeling of packaging configurations and long term stabilityAuthorship of technical documents such as analytical development reports, stability reports, and storage statementsManagement of reference standards and impurity markersManage and organize documentation and dataContribute to protocol development and oversight/troubleshooting of method transfersLiaise with Medicinal Chemistry, Bioanalytical, DMPK, and Preclinical departmentsCompliance with cGMP quality standards and internal SOPsTravel up to 5%Required QualificationsAdvanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field). BS with 10+ years, MS degree with 6+ years, or PhD with up to 4 years of relevant experienceExpertise in operation and maintenance of mass spectrometersExperience in HPLC operation and method developmentAbility to critically interpret data and articulate technical concepts in cross functional teamsAbility to ensure assigned activities are completed to the satisfaction of project timelinesStrong interpersonal skills that foster collaboration within and outside of the organizationBonus QualificationsExperience with accurate mass instrumentation such as Orbitrap Tribrid mass spectrometersExperience in operation of 2D-LCExperience in the determination of structures of small molecule impurities and/or metabolitesExperience protein and/or ADC characterization by mass spectrometryFamiliarity with gas chromatography, NMR, particle size analysis, solid state characterization, dissolution, ICP-MS/OES, and/or FTIRExperience with reference standard management, stability programs, and/or method validationFamiliarity with ICH guidelines, cGMPs, and pharmacopeial chaptersFit with Nurix Culture and ValuesStrong team orientation; highly collaborativeSolutions and results-oriented focusHands-on approach; resourceful and open to diverse points of viewSalary RangeScientist I : $123,841--$144,272Scientist II: $143,260 –$161,064Application ProcessNurix is an Equal Opportunity Employer offering a competitive salary and benefits package. 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