Process Development Scientist- Downstream

*TITLE: *Process Development Scientist- Downstream *LOCATION*: Frederick, MD *REQ#:* 22-001 *Overview*: Jecho Laboratories, Inc. (Jecho) is a biopharmaceutical company developing bio-similar, innovative therapeutic biologics, including therapeutic monoclonal antibodies, cytokines, immunotoxins, and vaccines to address a broad range of diseases as well as treatment of cancer and infectious disease. The company headquarter is located in Frederick Maryland, USA. We are seeking a Process Development Scientist to join our R&D team in Frederick, MD. Qualified individuals will execute small-scale downstream process development and analytical studies. The ideal candidate will exercise appropriate technical judgment in the design, execution, and interpretation of experiments. The candidate will receive general instructions from a supervisor for routine work and assignments. The candidate is expected to be eager to learn, highly productive, well organized, and self-motivated. *Essential Job Functions*: · Design and conduct experiments in protein and DNA/RNA therapeutics recovery and purification process development, and formulation development with an interdisciplinary approach spanning molecular and protein biology, protein and biomolecule separation, chemical and biochemical engineering, etc. · Perform column chromatography and various other routine physical and biochemical analysis on biological products, such as HPLC, SDS-PAGE, UF/DF, Western Blot, and ELISA. · Perform small-scale _E. coli _fermentation or mammalian cell bioreactor to generate protein materials for evaluation and characterization. · Design and perform protein stability analyses via protein size, conformation, homogeneity, and/or potency analyses. · Optimize protein formulation and/or storage conditions to improve protein stability. · Work with Discovery, Upstream Process Development, and Analytical Development to support material generation, design evaluation, cell line selection, product characterization and analyses. · Generate and maintain experimental data in a highly organized manner. · Prepare technical reports and present data and analyses, perform and support technology transfer activities, and report project status to senior scientists and management. *Minimum Requirements*: · A Ph.D. degree in biological or pharmaceutical science, biochemistry, bioengineering, human nutrition, or related fields. · 0-3 years’ experience in post-doctoral training or the pharmaceutical or biotechnology industry. · An in-depth understanding of antibody and recombinant protein structure and purification mechanisms. · Extensive hands-on experience with protein recovery and purification and analytical methods. · Working experience with biophysical characterization, product stability, and related microscopic and spectroscopic analysis techniques is a plus. · Extensive working experience with drug formulation, stability analysis, and delivery technologies. · Exhibited ability to propose, design, execute experiments and deliver a project in a timely manner with high quality. · Ability to work effectively in a team. Motivated and willing to work on a variety of tasks. · Experience working with DNA and/or RNA extraction, purification, and related processes is a plus. · Experience with model animals and surgical procedures is a plus. This position may require you standing/sitting/walking in the lab for routinely 8 hours and sometimes up to 12 hours, as well as lifting weight up to 30 pounds. *Compensation:* · Jecho offers a competitive salary and excellent benefits package, including health insurance, dental/vision insurance, short-term and long-term disability insurance, and 401(k) retirement plan. · Jecho is an equal opportunity employer. The job description is subject to change by the employer as the organizational needs and requirements of the job change. Job Type: Full-time Pay: $75,000.00 - $100,000.00 per year Benefits: * 401(k) * 401(k) matching * Dental insurance * Health insurance * Health savings account * Paid time off * Parental leave * Referral program * Tuition reimbursement * Vision insurance Schedule: * Monday to Friday Work Location: In person