Scientist - Screening & Analytical Chemistry
Scientist - Screening & Analytical Chemistry - Waltham, MA, Full-time Manus works across industries and value chains to accelerate the transition to BioAlternatives - better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of biotechnology today. We are seeking a Scientist in Screening & Analytical Chemistry to lead development of high-throughput analytical workflows. This role focuses on method development for rapid, targeted metabolite quantification and integration with screening pipelines. This hands-on position requires a desire and ability to work as an integral part of a multidisciplinary team, as well as the demonstration of a high degree of flexibility, creativity, and initiative. This person will be expected to play an integral part of Manus's research and development team located in Waltham, MA. Why work at Manus:Opportunity - For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.Accountability - You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.Passion - We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge. ResponsibilitiesDevelop and optimize analytical methods for targeted metabolite quantificationLead method development on GC/MS, GC-FID, and LC-QQQ-MS platformsDesign high-throughput analytical workflows with fast cycle timesDevelop sample preparation and derivatization strategiesWork with automation and screening teams to support microtiter plate-based fermentationsAnalyze and interpret large datasetsMentor junior staffInterface with instrument vendors to maintain uptime and optimal performanceAuthor SOPs and technical reports Basic QualificationsPhD in Analytical Chemistry, Chemistry, or related field ORMS with 8+ years or BS with 13+ years relevant experienceStrong experience in analytical method development Required Technical ExpertiseGC-FID and GC/MS assay development for targeted quantitation and metabolite profilingLC/QQQ-MS assay develop for targeted quantitationAssay optimization for speed, sensitivity, and throughput Preferred ExperienceExperience with high-throughput screening environmentsIntegration of analytical workflows with automationFamiliarity with liquid handling platformsExperience with LIMS (e.g. Benchling) and large datasetsIndustrial biotech or applied R&D experienceExperience with the following types of analytical instrumentationUHPLCGC-FIDGC/MSLC/QQQ-MSExperience with a variety of sample extraction and preparation techniques, applying automated solutions when appropriate, from complex matricesMicrobial fermentation brothMicrobial biomassPurified extracts