Scientist II - Structural Biology

CompanyNurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.Position SummaryThis role is located at the interface of Nurix’s DEL driven drug discovery engine and preclinical drug development platform. The strategic impact of this role is the elucidation and communication of small molecule interactions with drug targets to provide mechanistic understanding and guide design of clinical drug candidates. As a member of the early discovery department, you will make key contributions to validation and characterization of novel chemical matter for our targeted protein degradation platform. In addition to that, you will participate in multiple small and agile teams of drug discovery veterans and help achieve discovery and development milestones.Key ResponsibilitiesDesign and execute end-to-end gene-to-structure workflows: construct design, protein engineering, experimental planning, and structure determinationDetermine high-resolution structures of protein–ligand and protein complexes using X-ray crystallography and cryo-EMOwn all aspects of sample preparation, data collection, processing, model building, refinement, and documentationTranslate structural findings into actionable insights for project teams, and present results to colleagues and senior leadership in written and oral formatsPartner with computational chemistry and machine learning groups to drive rational drug design and enhance proprietary computational platformsServe as a structural biology resource across the research organization, providing mechanistic rationale to support project decisionsMaintain rigorous laboratory records and contribute to scientific reports, publications, and patent filingsHelp establish and continuously improve best practices, protocols, and SOPs within the structural biology groupBuild and maintain deep command of the structural mechanisms of protein ubiquitylation and degradationQualificationsRequired:MS with 8 or more years' relevant experience or PhD in structural biology, biochemistry, biophysics, or a related field; 4+ years of hands-on academic or industry experience. Exceptional candidates at the entry level will also be considered.Demonstrated deep expertise in X-ray crystallography, cryo-EM, or both. Independent deployment of both technologies is strongly preferredFull proficiency in Phenix, Coot, CryoSPARC, RELION, PyMOL, and Chimera/ChimeraXExceptional attention to detail, rigorous record keeping, and keen scientific curiosityStrong scientific communication skills with the ability to present complex structural data to diverse, cross-functional audiencesAbility to work strategically, independently, and collaboratively in a fast-paced, matrix research environmentPreferredExperience in drug discovery or biopharmaceutical setting is highly desirableExperience with protein degrader technologiesWorking experience with ubiquitin ligases, transcription factors, or membrane proteinsAdditional skills in SAXS, NMR, HDX-MS, machine learning, or computational structural biologyFit with Nurix Culture and ValuesCollaborative and team-oriented, eager to share expertise and learn from others. Solution-driven with a hands-on and resourceful approach. Adaptable and comfortable in a fast-paced, interdisciplinary environment. Committed to scientific excellence and the shared goals of the team. Salary RangeScientist II: $139,962--$159,890 (plus bonus, equity, and benefits)Location: Brisbane, CA - OnsiteApplication ProcessNurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).