Associate Scientist/ Scientist I – Antibody Discovery

The Antibody Discovery team at Tectonic is seeking a highly motivated and skilled Associate Scientist or Scientist I to aid in the discovery and engineering of innovative antibody therapeutics targeting GPCRs. Utilizing our novel GEODe technology, which enables the identification of functional antibodies to therapeutically relevant GPCR targets, this role will be central to our drug discovery pipeline. The ideal candidate will be an expert in utilizing antibody yeast surface display for naïve and affinity maturation campaigns, with a strong technical grasp of bio-layer interferometry (BLI) for detailed characterization of the binding kinetics of antibody hits. The candidate should be an independent and creative researcher, passionate about collaborating with a team at the forefront of molecular discovery, where their contributions will directly impact the development of next-generation GPCR targeting biologics.  About Tectonic Therapeutic: Tectonic is a clinical stage biotechnology company focused on the discovery and development of therapeutic proteins and antibodies that modulate the activity of G-protein-coupled receptors (GPCR). Tectonic’s founders are at the forefront of scientific research in biochemistry and molecular pharmacology. Their extensive track record of achievements includes major contributions to the development of multiple approved therapies for the treatment of cancer, autoimmune diseases and beyond. We believe a shared commitment to excellence and creativity is what makes meaningful scientific and medical advances possible. We work hard yet find time to laugh together as we drive toward achieving a common goal-improving human health. Key responsibilities to be successful in this role: Leading naïve and affinity maturation campaigns from large-scale yeast libraries using magnetic-activated cell sorting (MACS) and fluorescent-activated cell sorting (FACS). This will require the development and implementation of complex sorting and gating strategies to isolate rare, high-quality hits. Integration of next-generation sequencing (NGS), and subsequent data analysis, to track clone enrichment and diversity from yeast selection campaigns.Design and construction of next-generation yeast displayed naïve and affinity maturation antibody libraries.Utilizing BLI to perform high-throughput screening of hits and further detailed analysis of leads to characterize binding kinetics and map epitopes.Strong collaborations across groups for antigen design and downstream assays to ensure successful campaigns and thorough characterization of resulting clones. What you bring to the role:  Ph.D. with 0+ years of post-graduate relevant laboratory experience, or BS/MS with 6+ years of relevant industry experience. Title commensurate with experience. Deep understanding of, and significant hands-on experience with yeast display platforms for the discovery of antibody therapeutics, including library preparation (cloning, DNA isolation and transformations) and multi-color flow cytometry/FACS. Experience with NGS for sequence analysis of selection campaigns is highly desirable.Proficiency in operating and troubleshooting BLI platforms with a solid understating of binding experiments for protein-protein interaction analyses including kinetics, competition and epitope binning. Exceptional organization skills, proven ability to manage multiple tasks efficiently and maintaining a thorough well-organized experimental lab notebook (ELN).Excellent communication (both verbal and technical) and interpersonal skills to present complex protein engineering data to cross-functional teams.The ability to thrive in an agile, team-oriented matrix environment Interested applicants may write to jobs@tectonictx.com with an attached cover letter and CV in PDF format.We are an equal opportunity employer. All applicants will be considered for employment solely on the basis of on business needs, job requirements and individual qualifications, without attention to age, race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. Compensation: Targeted Base: $100,000 - $155,000** Base Compensation for this role will depend on a number of factors including a candidate’s qualifications, skills, competencies, and experience, and may fall outside of the range shown. Base pay is only one component of the company’s total rewards package, all regular employees are also eligible for the corporate bonus program or the incentive compensation program (if applicable), as well as equity. Additional benefits include health care, vision, dental, retirement, PTO, etc.