Supply Planning Manager

Position Summary:The Manager, Supply Planning is embedded within External Manufacturing organization. This individual will own the end-to-end supply planning function for Verve Therapeutics' clinical programs, operating in a fully outsourced CDMO model built on mRNA/LNP technology. The role is foundational to the team's S&OP process design and will serve as the primary driver of 18-month rolling MRP for clinical drug product supply.KEY RESPONSIBILITIESSupply Planning & MRPDevelop and maintain rolling supply plans for clinical drug productGenerate forward-looking material requirements for drug substance intermediates and critical excipientsManage supply plan assumptions, risk scenarios, and inventory coverage targets in alignment with program timelinesS&OP Process DevelopmentBuild and maintain S&OP templates, KPIs, and reporting dashboardsPrepare and present supply plan summaries for cross-functional leadership reviewsCDMO Network CoordinationTranslate supply plans into manufacturing schedules coordinated across external CDMOsMonitor schedule adherence, batch release timelines, and supply risk through collaborative CDMO governanceMaintain material genealogy and lot traceability across the multi-step supply chainRisk & Inventory ManagementDevelop safety stock strategies for critical materials, accounting for CDMO lead times, shelf-life/expiry constraints, and clinical trial uncertaintyIdentify and escalate supply risks with mitigation options framed for leadership decision-makingSupport annual reportable change and regulatory change management (CMC) from a supply continuity standpointQUALIFICATIONSRequiredBachelor's degree in Supply Chain, Engineering, Life Sciences, or related field; advanced degree a plus5+ years of supply chain or supply planning experience in pharmaceutical, biotech, or CDMO environmentHands-on experience with MRP/ERP systems (SAP strongly preferred)Direct experience with clinical supply planning in an outsourced manufacturing modelStrong analytical skills; proficiency with supply planning tools and Excel/dashboard platformsPreferredExperience with advanced therapy or biologic modalities (LNP, mRNA, gene therapy, oligonucleotide)Familiarity with S&OP/IBP process design and implementationExposure to CMC regulatory requirements (IND-stage) and supply risk classificationAPICS CPIM or CSCP certification