Research Scientist - Biochemistry & Biophysics

SyntheX is looking for a talented, enthusiastic, and highly motivated biochemist/biophysicist with a strong background in biophysical assay development and techniques including SPR to contribute to our drug discovery efforts.About UsSyntheX is expanding the frontier of drug discovery with target-centric, cell-based functional selection. Our proprietary ToRFLEx platform specializes in protein interaction modulation, identifying rare functional compounds with unique mechanisms of action – protein-protein interaction disruption and targeted protein degradation using molecular glues. The technology is broadly applicable to several indications, and our internal focus has been on oncology. We're seeking to modulate well established and genetically validated targets using novel pharmacology that leads to more durable and safer clinical outcomes for patients.We are a fast growing startup located in the Mission Bay neighborhood of San Francisco. Additional information can be found on www.synthexlabs.com.Requirements• Ph.D., Biochemistry, Biophysics, Molecular Biology or closely related field with expertise in biophysical assays, specifically Surface Plasmon Resonance (SPR), Biacore preferred• 5+ years of lab experience in demanding, analytical work environment is preferred• 2+ years of biotech start-up or industry experience is highly valued, but not a prerequisiteSkills and Experience• Experience using biophysical techniques to analyze protein-protein interactions as well as protein-small molecule interactions; using techniques such as Surface Plasmon Resonance (SPR), Homogeneous Time-Resolved Fluorescence (HTRF), AlphaScreen, Microscale Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), and Fluorescence Polarization/Anisotropy (FP) is preferred• Expertise with the kinetic and thermodynamic characterization of ligand binding as well as quantitative data management and analysis• Experience completing in vitro high-throughput screens (HTS) of large small molecule libraries using HTRF or AlphaScreen, from design to execution, analysis, and validation is a plus• Biochemistry skills with experience in recombinant protein expression and purification, enzymology, and protein chemistry using various expression systems• Adhering to good documentation and lab note keeping standards• A passion for science!Responsibilities• As a key team member, the candidate will be involved in designing, optimizing, establishing and executing a wide-range of biochemical and biophysical assays to support our discovery programs• Think critically and creatively to generate and execute ideas to positively impact project goals• Independently select appropriate methods and techniques in performing experiments• Recommend alternatives; research new methods and techniques and proactively seeks out potential solutions to problems• Independently write technical reports and technical presentations within the area of expertise• Provide regular project updates in team meetings• Work independently and effectively on multiple programs in a dynamic environment• Train and manage research assistants focused on protein purification and biophysical assays• Demonstrate strong motivation, attention to detail, independent thinking, and the ability to fully integrate into a high achieving team environment• Possess strong scientific and laboratory skills with a keen eye for detail and a passion for science, innovation and learningDevelopment OpportunitiesThis role offers a unique opportunity to be part of growing a company. It offers significant exposure to new scientific research and development. A successful candidate will have the opportunity for career progression and professional growth as the company grows. It is an opportunity to work with a small, dedicated, and diverse professional team working towards the goal of expanding the drug discovery toolkit and helping advance therapies to patients.