Scientist, Functional Genomics

Company infoNewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.DescriptionNewLimit is seeking an experienced cell and molecular biologist with a background in functional genomics to join our Epigenetic Editing team. Our therapies restore cell function by reprogramming the epigenome with both natural transcription factors and programmable editors. You will be instrumental to the discovery and development process for this new class of medicines.As a Member Of Our Team, You WillRun the largest reprogramming screens in the world in collaboration with our Single Cell Genomics and Predictive Modeling teamsDevelop methods for the construction, delivery, and control of epigenetic reprogramming payloads for single cell screens in primary mammalian cellsBuild and deploy molecular tools at a massive scaleDesign and implement functional genomics screens to measure the effect of epigenetic reprogramming on the molecular and functional state of primary mammalian cellsContribute to the design and formulation of therapeutic molecules (e.g. mRNA synthesis and optimization, lipid nanoparticle formulation)RequirementsPh.D. in molecular biology, cell biology, or a related field or equivalent industry experience (5+ years)Experience with functional genomics approaches for pooled or arrayed screening (e.g. one of: CRISPR-Cas pooled fitness screens, gene expression perturbation profiling, Perturb/CROP-seq, or similar methods)Experience with molecular cloning, next-generation sequencing, and associated molecular biology methodsExperience with in vitro and in vivo transgenic delivery methods for mammalian cells (at least one of: lentivirus, AAV, AdV, transposition systems, lipid nanoparticles, or similar)Nice to haveExperience with epigenetic reprogramming methods using transcription factors for cell fate engineering or CRISPR-Cas tools for targeted epigenetic editingExperience working with primary cells and tissue samplesExperience with single cell genomics methodsPython programming and Unix workflow management skillsTherapeutics development experienceBenefitsNewLimit offers generous benefits to ensure our team can focus on our mission:Health, dental, and vision insurance401(k) with company matchPaid parental leaveIndustry-leading paid time off (PTO) — 20 days/year for all employees + holidaysMeals and snacks on-siteSalary Range: $130,000 to $170,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.