Vice President of Global Supply Chain (Sunnyvale)

Position Overview We are seeking a strategic and execution-oriented Vice President of Global Supply & External Manufacturing to lead the development and scaling of our end-to-end supply chain and external manufacturing network. This individual will be responsible for ensuring reliable, compliant, and cost-effective supply across clinical and commercial programs, spanning multiple therapeutic modalities. The VP will play a critical leadership role in building and managing a global network of CDMOs, driving tech transfer and commercialization readiness, and partnering cross-functionally with CMC, Quality, Regulatory, and Clinical Operations to support the advancement of our pipeline. Key Responsibilities Global Supply Strategy Define and execute the global supply chain strategy across clinical and commercial stages Establish scalable supply models to support pipeline growth and product launches Lead S&OP processes, demand planning, and inventory strategies across regions External Manufacturing Leadership Build and oversee a global network of CDMOs for drug substance, drug product, and fill-finish operations Lead CDMO selection, qualification, contracting, and ongoing performance management Establish governance frameworks, KPIs, and business review processes with external partners Tech Transfer & Scale-Up Oversee all technology transfer activities from internal development to external manufacturing partners Ensure successful scale-up from early clinical through commercial production Drive process robustness, reproducibility, and manufacturing readiness Clinical & Commercial Supply Ensure uninterrupted supply of clinical trial materials globally Lead commercialization readiness efforts, including launch supply planning and distribution strategy Develop supply continuity and risk mitigation plans, including dual sourcing strategies Regulatory & Quality Alignment Partner closely with Quality and Regulatory teams to ensure compliance with FDA, EMA, and global health authorities Support CMC sections of regulatory filings (IND, BLA, MAA) Ensure inspection readiness across all external manufacturing sites Financial & Operational Excellence Own and manage supply chain and external manufacturing budgets Drive cost of goods optimization and long-term cost reduction strategies Lead contract negotiations and manage multimillion-dollar CDMO agreements Leadership & Cross-Functional Collaboration Build, lead, and develop a high-performing global team across supply chain and external manufacturing Serve as a key member of the Technical Operations leadership team Collaborate cross-functionally with CMC, Clinical, Commercial, and Finance to align on program priorities Qualifications Required Bachelor’s degree in Engineering, Life Sciences, or related field; advanced degree preferred 15+ years of experience in biopharmaceutical manufacturing, supply chain, or technical operations Significant leadership experience in external manufacturing and CDMO management Proven track record supporting products from early development through commercialization Deep understanding of global regulatory requirements and GxP compliance Experience managing global supply chains across multiple regions Demonstrated ability to lead large, cross-functional teams and influence at the executive level