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Process development and manufacturing experience includes mammalian and/or microbial cell culture and scale up, the isolation and purification of proteins, antibodies, etc., extensive experience with product recovery (depth filtration, centrifugation, MF), TFF (UF/DF), chromatography (Affinity, IonX, HPT, HIC.
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Providing routine troubleshooting and maintenance of process development instruments including reactors, HPLCs, purification skids and UF/DF manifolds. Successful candidates will be a part of a dynamic and enthusiastic team responsible for development, scale up and tech transfer of the ECO Synthesis™ platform.
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Summary: We look forward to welcoming a Bioprocess Engineer with a solid understanding of bio-chemical engineering fundamentals and modeling expertise to support our laboratory, pilot and clinical scale process development, technology transfer to internal and external GMP production facilities for our novel cell free expression-based therapies.
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Participate in design of experiments for chromatography, harvest clarification, virus removal filtration, UF/DF, and any other required downstream process steps. Participate in tech transfer, facility fit, and process scale up/ scale down.
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The Amgen Rhode Island Drug Substance Pilot Plant provides critical technical support for team supply, commercial process development, technology transfer, process characterization, and scale-up / scale-down activities.
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Perform pilot scale downstream purification process and manufacturing (post cell lysate to final formulation) by utilizing column chromatography, CsCl, UFDF, and various filtration steps. Hands on experience with buffer preparations, TFF (Hollow Fiber/Cassettes), UF/DF and Column Chromatography Purification.
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Direct experience with upstream development (USP) for biologics such as stable cell line development, cell culture process development (bioreactor) and scale-up. Direct experience with downstream development (DSP) for biologics such as UF/DF & TFF at benchtop and manufacturing scales, and liquid chromatography for protein purification.
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With one of the largest Jewish student populations in the country, the opportunities for Jewish life at UF are nearly limitless and UF Hillel strives to operate on a scale capable of meeting this challenge.
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Come join us on this journey to transform the enzyme engineering landscape for the betterment of human health. BS or equivalent in Chemical Engineering, Biology, Biochemistry or relevant scientific field with a minimum of 1 year of relevant industrial/academic experience in a laboratory environment.
$75,000 - $95,000 a yearFull-timeExpandApply NowActive JobUpdated 10 days ago - UpvoteDownvoteShare Job
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Job Opening Qualifications Education: Diploma/associate's degree Licensure/Certification/Registration: Florida registered nurse license BLS ACLS NIH Stroke Scale Special Skills/Qualifications/Additional Training/Experience Required: Must be able to read, write in, speak and understand English.
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We are establishing commercial processes that require a solid practical foundation in standard bioprocess unit operations ( e.g. UF/DF, normal flow filtration, mixing systems, chromatography). Our team looks forward to welcoming an experienced Bioprocess Engineer with a strong background in the regulated (bio)pharmaceutical environment supporting laboratory, pilot and commercial scale process development, mRNA technology transfer to internal and external GMP production facilities and commercial production of mRNA therapies.
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Previous knowledge of oligonucleotide synthesis, HPLC, UF, conjugation, and lyophilization is advantageous. Actively involved in aspects of technology transfer and scale-up of oligonucleotide manufacturing processes delivered from Manufacturing Technical Services into Manufacturing.
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We are seeking a Downstream Technician II responsible for expanding our lab-scale recovery capabilities to remove or recover micro-organisms and bioactives from broth generated at our Fermentation Research Facility in Wilmington, DE.
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The remit of this role includes management of the team and partnership with its leadership and the Technology team to drive controls, automation and continue building scale. Determine UF commitments by private capital feeder funds/hedge feeder fund subscriptions into the underlying funds.
$250,000 - $350,000 a yearFull-timeExpandApply NowActive JobUpdated 15 days ago - UpvoteDownvoteShare Job
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Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver technology platform to discover, develop and enhance novel, high-performance enzymes and other classes of proteins.
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