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Oversee the development ofin vitro and in vivo pre-clinical models across multiple therapeutic areas. The successful candidate is a confident leader with extensive prior success in drug discovery, preferably in multiple therapeutic areas such as immunology, oncology, metabolic diseases, CNS, etc.
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These will include but are not limited to primary tissue processing, flow cytometry and cell sorting, single-cell RNA/DNA/protein/ATAC-sequencing data generation, sequencing library construction, bulk RNA extraction and analysis, human specimens processing and analysis for RT-PCR, cell cultures for in vitro and in vivo experiments, CRISPR screens, western blotting, immunohistochemistry and image analysis.
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Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management. Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system.
$21 - $50 an hourFull-timeExpandApply NowActive JobUpdated 3 days ago - UpvoteDownvoteShare Job
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Previous course work in immunology, microbiology cell biology, biochemistry, virology and chemistry is desirable. The Production Technician has primary responsibility for production of in-vitro medical diagnostic products in accordance with current manufacturing directions, SOPs, GMPs, and QSR to meet or exceed quality specifications on schedule at or below standard costs.
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The Role:A Senior Scientist in the POC AssayDevelopment group is a highly technical and specialized role responsible fordesigning, maintaining, and troubleshooting in-vitro diagnostic products in thePoint-of-Care space.
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These include intellectual input and decision-making on protein targets to be pursued, development of immunogens and immunization strategies, utilization of hybridoma technology, and antibody validation in vitro and in vivo.
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10 Diagnostics locations throughout the US.#1 market leader for in-vitro diagnostics. 10 Diagnostics locations throughout the US.#1 market leader for in-vitro diagnostics. Our success in creating a truly diverse and inclusive workplace will directly impact our ability to deliver on our purpose of “Doing Now What Patients Need Next.”Facts & Figures:Headquartered in Basel, Switzerland with 100,000 employees worldwide.
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We are seeking a highly motivated, dedicated and collaborative scientist with knowledge and expertise in cellular and molecular immunology, with experience in antibody/small molecule drug discovery.
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Immunologist and/or genetics/genomics expert : will analyze genetic variants and their effects on enhancer and promoter function in immune cells in vitro , through performing massively parallel reporter assays and high-throughput CRISPR screens in human primary T cells from IBD patients and healthy controls.
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The Coufal lab studies neuroimmunology and the role of microglia, the inflammatory cell type of the brain, in neurodevelopment, aging, and both idiopathic and genetic neurologic disease using a variety of in vitro and in vivo models and stem cell derived microglia.
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Responsible for data review, analysis and interpretation of in vitro and in vivo results, and troubleshooting issues related to drug discovery projects. A strong background in immunology drug discovery.
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Conduct/execute in vitro, ex vivo and/or in vivo studies to facilitate drug discovery and development with some independence. 3+ years of experience in cell biology, molecular biology, immunology, pharmacology or a related field of biology.
$65,000 - $78,000Full-timeExpandApply NowActive JobUpdated 3 days ago - UpvoteDownvoteShare Job
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The candidate’s main responsibilities will include: a) novel assay development, b) in-vitro T cell circuit design and validation, c) establishment of in-vivo tumor models, d) compiling pre-clinical results to support the designation of clinical vector design, and e) leading the in-vitro and in-vivo pharmacology characterization of therapeutic product candidates in collaboration with a process development team towards an IND filling.
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Principal Investigator of Immunology, Therapeutics, Large Molecule, Flow Cytometry, In Vivo, In Vitro, Western Blot, ELISA, PCR, Research, Science, Comprehensive Benefits Package, Health, Vision, Dental.
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In vitro work includes a range of cellular assays, including multi-parametric flow cytometry and molecular biology techniques to help interpret in vivo observations. Bachelor’s Degree in Biochemistry, Bioengineering, Biology, Cell Biology, Immunology, Molecular Biology, or a related subject area and 4 years of scientific laboratory experience.
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