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In this vital role, you will be a part of a fast-paced, integrated, and interactive research group exploring therapeutics for immuno-oncology programs. In vitro work includes a range of cellular assays, cell culture including multiparametric flow cytometry and molecular biology techniques to help interpret in vivo observations.
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Additionally, the laboratory now has a major focus in the field of immuno-oncology, evaluating multiple innovative cell-based immune therapy approaches in targeting ovarian cancers.
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Terremoto Biosciences is looking for a talented Associate Scientist/Scientist, In Vivo Pharmacology. The position would be a key member of the In Vivo Pharmacology team and report to the Head of In Vivo Pharmacology.
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Lab-based role: Independently design and execute experimental strategies, using cellular and molecular immunological techniques, to investigate target biology and therapeutic mechanisms of action in in vivo immuno-oncology models.
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The Director will manage all internal and/ or external in vivo workflows, collaborating with various teams within Moderna, including Cancer Vaccine Research, Immuno-Oncology Research, and Research Operations.
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Manages studies with highly technical components and expanded endpoints such as Immuno-oncology and Hematological studies involving ex-vivo analyses including but not limited to 2D/3D cell assays, Luminex, ELISA and flow cytometry.
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Responsible for the development and execution of a range of Pharmacology studies including cell-based screening assays, immune cell bioassays, PK/PD assays and disease models for immuno-oncology, autoimmune and other in vivo immune-related disease models such as Tumor growth inhibition studies in humanized NSG tumor mice and autoimmune models.
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The Senior Scientist of Pharmacology will be responsible for the assessment of engineered protein therapeutics in autoimmune/inflammatory disease mouse models and mouse models of immuno-oncology.
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You will maintain expertise in regulatory requirements and preclinical safety approaches applied to Immuno-Oncology therapeutics and awareness of industry trends. The group supports early safety assessment of T Cell Engagers, Immuno-Oncology Therapeutics, Cell Therapies.
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Hands on experience in immuno-oncology in vitro techniques (mammalian cell culture; primary cell isolation) and in vivo models (animal handling; various injection techniques; blood collection) of oncology and/or cancer immunotherapy.
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Associate Scientist-Oncology (In Vivo Pharmacology) In vitro work includes a range of cellular assays, including multi-parametric flow cytometry and molecular biology techniques to help interpret in vivo observations.
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You will use your knowledge and experiences in immuno-oncology to design and conduct experiments with the ultimate goal of make better medicines faster. Independently design, troubleshoot, and execute in vitro and ex vivo assays to narrow down promising hits from large antibody panels.
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An established record of safety science in an academic or industry setting with experience of the application of in vitro and/or in vivo models is essential. Experience with the design and execution of in vivo studies to determine the effects of T Cell Engagers on biological systems with line of sight to human safety may be considered an advantage.
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This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development.
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Broad knowledge of cell culture techniques is required and knowledge of how to utilize in vivo oncology models is desirable. Leverage state-of-the-art immuno-oncology approaches to develop insights into new IO-related targets and impacts on novel therapeutics on the immune system.
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