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Experience with downstream purification of biological molecules desired. Under the general scientific and administrative direction of Principal Scientist in Downstream and working in conjunction with internal and external partners, this individual will support these late stage and commercial biologics program activities within BPDC. The individual will develop and demonstrate scientific, experimental and tech transfer skills focusing on downstream processing.
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Direct experience with downstream development (DSP) for biologics such as UF/DF & TFF at benchtop and manufacturing scales, and liquid chromatography for protein purification. Direct experience with upstream development (USP) for biologics such as stable cell line development, cell culture process development (bioreactor) and scale-up.
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Manufacturing cGMP production activities include solution preparation, master/working cell bank production, upstream cell culture, downstream protein purification, mRNA and molecular therapeutics production, and small-scale fill/finish.
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The business includes our proprietary GPEx cell line engineering platform, our new state-of-the-art biomanufacturing facility in Madison, WI, and our market leading biologics analytical services as well as SMARTag Antibody Drug Conjugate technology in Emeryville, CA. Leveraging our growing differentiated technology portfolio, world class manufacturing capability, and other integrated services across the Catalent network, Catalent Biologics is positioned to drive significant growth for Catalent.
Full-timeExpandApply NowActive JobUpdated 9 days ago - UpvoteDownvoteShare Job
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Experience with mammalian, insect, yeast, or bacterial cell lines and their cultivation and/or purification of biologics or viral vectors produced from such preferred. The Manufacturing Supervisor may be assigned to work directly with Upstream, Downstream or Buffer Preparation Unit Operations.
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Please describe your familiarity with biologics processing at-scale equipment in solution preparation, cell culture, purification and/or equipment cleaning/preparation areas. Responsibilities:As a key member of our team, you'll take on a diverse range of responsibilities that encompass Upstream, Downstream, and Core Support functions.
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This position is a hands-on role, and the successful candidate will have deep knowledge and experience in long oligonucleotide purification and downstream processing to advance our cutting-edge gene editing drug discovery programs.
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Good understanding and knowledge of the Biopharmaceutical /Biotech Industry and strong, working knowledge of chromatography plus hands-on experience in protein purification. Do you have a passion for protein purification and Bioprocess.
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Familiarity with cell culture processes equipment such as bioreactors and downstream equipment for protein purification such as AKTA Pure/Avant is desirable. POSITION DUTIES & RESPONSIBILITIES:Executes cell culture and purification process development studiesExecutes small scale lab experiments following Standard Operation Procedures(SOPs) and laboratory batch records (LBRs)Follows laboratory safety protocolsCollaborates with development scientists and cross-functional team membersOrganizes and analyzes data from process development studiesWorks with minimal supervision after training.
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RESPONSIBILITIES Laboratory Scale Cell Culture experience, ProteinA purification experience, spectroscopy such as FTIR or UV, coursework in analytical chemistry, physical chemistry, and statistics The candidate will be responsible for operating lab-scale bioreactors, including daily sampling activities, bioreactor assembly, and harvest of bioreactors.
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Hands on experience with ADC chemistry, reaction processes and purification methods (i.e., Tangential flow filtration, chromatography, etc. The successful candidate will be responsible for the development of scale-able and robust downstream ADC processes and support technology transfer efforts, leading to clinical GMP manufacturing of ADCs.
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Basic interactions Manufacturing Cell Culture, Manufacturing Purification, Manufacturing Compliance, Engineering & Technology, Supply Chain, Quality Assurance, Quality Control. Executes fundamental unit operations in Downstream manufacturing related to the manufacturing of bulk drug substance in a multi-product facility.
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Engineering is responsible for supporting CGMP operations through process engineering, facilities and utilities engineering, calibration, process improvement and automation, packaging, capital projects, while maintaining compliance with regulatory standards.
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Prepares and autoclaves equipment for tissue culture, purification, and filling. Ability to work independently and within team (role will work with upstream and downstream team). Prepares and autoclaves equipment for tissue culture, purification, and filling.
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Experience with downstream chromatography and protein purification preferred. Experience with downstream chromatography and protein purification preferred. Process Controls and Validation Engineers provide technical support to manufacturing, quality and CMC Regulatory for manufacturing processes from technology transfer and/or design transfer to post-commercial lifecycle management activities.
ExpandApply NowActive JobUpdated 7 days ago
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