MUSC

Job Description Summary Individual will be self-motivated to learn and launch glycoproteomic studies by chromatography coupled to tandem mass spectrometry (LC-MS/MS) on timsTOF-fleX instrumentation.. Experience with any single topic or all: neurobiology, cancer, glycoproteomics, big data analytics, biostatistics, bioinformatics desired.. Techniques available to learn single cell mapping by mass spectrometry approaches, multiplexed antibody reporting, and biomarker approaches.. Individual will be familiar with processes of proteomic curation including de novo MSMS interpretation, search parameters to reduce false discovery, peptide and protein probability evaluation, and post-translational modification assessment.. 20% - Sample preparation for chromatography coupled to tandem mass spectrometry.

pharmacology

Job Description Summary Individual will be self-motivated to learn and launch glycoproteomic studies by chromatography coupled to tandem mass spectrometry (LC-MS/MS) on timsTOF-fleX instrumentation. Experience with any single topic or all: neurobiology, cancer, glycoproteomics, big data analytics, biostatistics, bioinformatics desired. Cell culture experience desired. Techniques available to learn single cell mapping by mass spectrometry approaches, multiplexed antibody reporting, and biomarker approaches. Entity Medical University of South Carolina (MUSC - Univ) Worker Type Employee Worker Sub-Type​ Regular Cost Center CC001034 COM PHARM Operations CC Pay Rate Type Salary Pay Grade University-00 Pay Range $0 - $0 - $0 Scheduled Weekly Hours 40 Work Shift Job Description Job Duties: 25% - Perform liquid chromatography and tandem mass spectrometry.  Individual will be familiar with system suitability, quality control for studies. Individual will be able to select appropriate columns and understand principles of chromatographic separation. 25% - Data analysis and new software testing and development. Individual will be familiar with proteomic search algorithms MSFragger, Byonic, Maxquant. Individual will be familiar with processes of proteomic curation including de novo MSMS interpretation, search parameters to reduce false discovery, peptide and protein probability evaluation, and post-translational modification assessment. 20% - Sample preparation for chromatography coupled to tandem mass spectrometry. Individual will be familiar with sample homogenization, reduction and alkylation. Individual will have experience with solid phase extraction as a cleanup process. Individual will be able to rigorously follow protocol per sample type. 10% - Personal growth development, conference attendance, grants, manuscript writing 10% - Mentoring and training of others 10% - Lab safety Minimum Requirements:  PhD/MD or equivalent Additional Job Description Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required. If you like working with energetic enthusiastic individuals, you will enjoy your career with us! The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need. Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees

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