RPMGlobal

We are seeking an experienced and motivated Bioinformatics Scientist to join our Data Analysis Team (DAT). to drive next-generation sequencing (NGS) assay development for LDT and IVD tests.. Collaborate with R&D and product development teams to integrate bioinformatics solutions into the assay development process.. Develop, implement, and validate bioinformatics pipelines, including data processing, QC, analysis, and interpretation of NGS data.. Proficiency in machine learning, development of novel bioinformatics methodologies, and algorithms development, including benchmarking of computational methods (best practices to prevent over-fitting, construction of truth sets, generation of benchmark data by simulation).

assay development

Location: South San Francisco
Department: Research & Development - Bioinformatics
Description At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte – whether it be in one of our labs, corporate offices, the field, or remote – enables our employees to not only make a meaningful impact on the lives of patients, but to also learn and grow within a results-driven environment that values innovation, collaboration, and compassion.
The Position
We are seeking an experienced and motivated Bioinformatics Scientist to join our Data Analysis Team (DAT) to drive next-generation sequencing (NGS) assay development for LDT and IVD tests . The successful candidate will play a crucial role in designing, developing, and optimizing our next generation of genomic assays . This position requires a unique blend of expertise in bioinformatics, extensive experience in assay optimization, analytical assessment and validation, a deep understanding of molecular biology, and a passion for transforming complex biological data into actionable insights. This position can be located onsite in our San Francisco office. We are also open to hybrid or remote.
KEY RESPONSIBILITIES:
Drive development study design and all analysis for assay development effort in collaboration with cross-functional teams.
Employ statistical and machine learning techniques to comprehensively evaluate assay performance and create optimization strategies. Collaborate with R&D and product development teams to integrate bioinformatics solutions into the assay development process.
Develop, implement, and validate bioinformatics pipelines, including data processing, QC, analysis, and interpretation of NGS data. Facilitate Software & IT teams for successful pipeline deployment in production.
Conduct rigorous bioinformatics analysis and present findings to stakeholders.
Stay abreast of the latest developments in bioinformatics, genomics, and assay technologies, and leverage this knowledge to propose innovative solutions.
Who You Are
REQUIRED EXPERIENCE:
PhD or MS in bioinformatics or an adjacent data science field, such as biostatistics or computer science.
Minimum 5 years of relevant post-graduate experience (preferably with some industry experience).
Proficiency in quantitative transcriptomics from NGS or expression microarray data in human disease/biology specifically, such as: differential expression, dimension reduction, expression-based classifier development, RNA-based signatures, cell type deconvolution.
Proficiency in machine learning, development of novel bioinformatics methodologies, and algorithms development, including benchmarking of computational methods (best practices to prevent over-fitting, construction of truth sets, generation of benchmark data by simulation).
Demonstrated record of technical and scientific leadership, ownership, and independent work.
RELEVANT EXPERIENCE (preferred but not required):
Track record of working with wet lab scientists on iterative experiment design, execution, analysis, and interpretation as a tightly integrated team.
Thorough understanding of NGS technologies and various methods for library preparation (WGS, enrichment, RNA-Seq, methylation, etc.).
Proficiency in genomics, sequence analysis, and secondary analysis, such as: variant calling (e.g., SNVs/MNVs/indels, CNV, structural variants), NGS QC, splicing, circular nucleic acids.
Strong understanding of germline and somatic mutation processes leading to complex variation and genome-wide biomarkers with potential clinical utility, such as TMB, mutational signatures, LOH.
Proficiency with high-intensity computing in AWS, Dockerized workflows, and Linux.
Strong programming skills in R, Python, and any flavor of SQL.
Excellent communicator about complex technical topics in an interdisciplinary setting, especially by using data visualizations and diagrams.
Excellent technical problem solving and troubleshooting skills.
Passion for Innovation : You are deeply curious and driven to explore uncharted territories in genomics. Your passion for discovery motivates you to use novel analytical approaches to bring new insights to assay optimization and evaluation.
Collaborative Spirit: You thrive in a collaborative environment, bringing a positive, can-do attitude to interdisciplinary projects. You are skilled at communicating complex ideas to non-experts and active listening, fostering an inclusive atmosphere that values each team member's contribution. You are receptive to feedback and motivated to better serve the team’s needs.
Adaptability : In our fast-paced industry, change is constant. You are agile and flexible, ready to pivot strategies in response to new data or technologies. Your resilience and open-mindedness help our team navigate the uncertainties inherent in groundbreaking research.
What We Can Offer You
Veracyte is a growing company that offers significant career opportunities if you are curious, driven, patient-oriented and aspire to help us build a great company. We offer competitive compensation and benefits, and are committed to fostering an inclusive workforce, where diverse backgrounds are represented, engaged, and empowered to drive innovative ideas and decisions. We are proud to have been named a “Bay Area Top Workplace” for ten years in a row by the Bay Area News Group and “Best Places to Work in San Diego” in 2023 by the San Diego Business Journal.
The anticipated base salary range for candidates who will work in San Francisco is $145,000 to $198,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Base pay is one part of the Total Package that is provided to compensate and recognize employees for their work, and this role may be eligible for additional discretionary bonuses/incentives, and restricted stock units.
Veracyte is a multi-state employer, and this salary range may not reflect positions that work in other states.
About Veracyte
Veracyte (Nasdaq: VCYT) is a global genomic diagnostics company that improves patient care by providing answers to clinical questions, informing diagnosis and treatment decisions throughout the patient journey in cancer and other diseases. The company’s growing menu of genomic tests leverage advances in genomic science and technology, enabling patients to avoid risky, costly diagnostic procedures and quicken time to appropriate treatment. The company’s tests in lung cancer, prostate cancer, breast cancer, thyroid cancer, bladder cancer and idiopathic pulmonary fibrosis are available to patients and its lymphoma subtyping and renal cancer tests are in development. With Veracyte’s exclusive global license to a best-in-class diagnostics instrument platform, the company is positioned to deliver its tests to patients worldwide. Veracyte is based in South San Francisco, California. For more information, please visit www.veracyte.com and follow the company on Twitter (@veracyte).
Veracyte, Inc. is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability status. Veracyte participates in E-Verify in the United States. #J-18808-Ljbffr

START NEW SEARCH