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Senior Scientist, Biomarker Assay Development
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Full-time
- The Bioanalytical Sciences group at Alnylam is seeking a highly motivated Senior Scientist, specializing in ligand binding assays to quantify proteins, peptides, antibodies, and oligonucleotides.
- This individual will be responsible for designing, developing, and implementing fit-for-purpose methods across various technologies, such as ELISA, MSD, Luminex, ELLA, Quanterix, to support early through late-stage drug development programs to inform on target engagement, pharmacodynamics, pharmacokinetics, mechanism of action, and safety, to advance RNAi therapeutic development.
- Independently develop and qualify novel ligand binding assays (ELISA, MSD, Luminex, Quanterix), in a variety of biological matrices to support the analysis of drug PD, and inform on target engagement.
- Aid in critically reviewing and troubleshooting internal and external ligand-binding assays and biomarker methods.
- Author SOPs and reports for protein PD and biomarker methods used in IND filings, and support method transfers to CROs, as needed.
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