Qilu Pharmaceuticals

· Essential skills includes: RT-qPCR, ELISA, Western blot, cell culture, necropsy. · Perform preclinical candidate screening of siRNAs leading to lead compound selection via combined in vitro and in vivo assays, working with or supported by cross-disciplinary groups, including chemistry, bioassay, histology, and in vivo pharmacology, and/or CROs. · PhD in molecular biology, pharmacology, or related discipline with 1+ years of experience in pharmaceutical/biotech industry or 3+ years of experience as a post doc.. · In vivo screening to utilizing a variety of routes of administration is desired (i.v., i.p., s.c., i.t., i.c.v.), and experience performing hydrodynamic injections is preferred.. · Assay development to support preclinical and nonclinical efforts

senior principal scientist

Qilu Pharmaceuticals is a leading pharmaceutical and biopharmaceutical company in China, with 3 innovation centers in the US. We are seeking US-based experienced and self-motivated professionals to join our siRNA team. The successful candidate will be a key member of the drug discovery group and will lead efforts of advancing siRNA therapeutics to treat intractable diseases including liver diseases, neurological diseases and ocular diseases. Primary Responsibilities · Responsible for nominating targets for diseases/indications for liver and extrahepatic tissues · Determine mechanism of action for drug targets; design and execute proof-of-concept studies to validate targets together with internal and/or external partners · Essential skills includes: RT-qPCR, ELISA, Western blot, cell culture, necropsy · Preferred skills: stem loop qPCR, co-immunoprecipitation, metabolic disease modeling, and hydrodynamic injections in mice · Perform preclinical candidate screening of siRNAs leading to lead compound selection via combined in vitro and in vivo assays, working with or supported by cross-disciplinary groups, including chemistry, bioassay, histology, and in vivo pharmacology, and/or CROs · Lead projects from inception to preclinical candidate nomination · Effectively manage multiple projects in parallel and deliver quality results within sensitive timelines · Comply with appropriate SOPs; train associates to meet requirements; present research findings to project teams, governance bodies, or external meetings · Effectively communicate across all organizational levels Qualification · PhD in molecular biology, pharmacology, or related discipline with 1+ years of experience in pharmaceutical/biotech industry or 3+ years of experience as a post doc. The level of position will be determined by previous experience and achievements. · Ability to conduct in vitro screens (qPCR) in a 384 well format and identify leads as well as integrate counter screen data to select candidates · In vivo screening to utilizing a variety of routes of administration is desired (i.v., i.p., s.c., i.t., i.c.v.), and experience performing hydrodynamic injections is preferred. · Experience screening siRNA or ASOs is highly preferred; experience of gene/base editing is a plus · Track record of independent research and creativity, as demonstrated by quality publications and/or patents · Mechanistic understanding of metabolic diseases in liver highly preferred · Assay development to support preclinical and nonclinical efforts · Outstanding organizational and time management skills and must be a self-starter with the ability to thrive in a multi-disciplinary, collaborative, fast-paced, and team-oriented environment. · Excellent verbal and written communication skills

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