Century Therapeutics, Inc

Position Title: Scientist/Sr. Scientist, Immunology & In-vitro Pharmacology. Direct experience with functional immune assays and multi-color flow cytometry is essential.. Experience with cytotoxicity assays and MSD or ELISA is strongly preferred.. Multi-color flow panel design. Hands on knowledge of advanced flow cytometry methods, including multi-color (8+ color) panel design and analysis, as well as ICC for phospho-flow, cytokine, transcription factor studies.

sr scientist

Position Title: Scientist/Sr. Scientist, Immunology & In-vitro Pharmacology Reports to: Associate Director, Immunology & IVPCompany Background: Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Centurys genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care. Centurys foundational technology is built on induced pluripotent stem cells (iPSCs) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform differentiates Century from other approaches that utilize non-renewable donor-derived cells. Role: The Scientist will be part of Centurys Immunology / In-Vitro Pharmacology team and will be responsible for leading a small team. The candidate will coordinate with other teams to receive cell material for assessment of fitness and function. They will also conduct research activities aimed to identify novel opportunities for product improvement. The ideal candidate will bring expertise in NK and/or T cell immunobiology with a record of laboratory team leadership. Direct experience with functional immune assays and multi-color flow cytometry is essential. Experience with cytotoxicity assays and MSD or ELISA is strongly preferred. Responsibilities: <ul><li>Lead in vitro pharmacology and/or immunology effort for therapeutic program </li><li>Manage small team of research associates </li><li>Functional assessment of cell products </li><li>Cytotoxicity </li><li>Persistence </li><li>Serial Killing </li><li>Signaling </li><li>Cell health / cell cycle </li><li>Cytokine secretion (MSD) </li><li>Cell culture (primary cells and immortalized tumor cells) </li><li>Multi-color flow panel design </li><li>Phenotypic characterization of cell products </li><li>Assay development </li><li>Drafting technical reports </li><li>Presenting results internally and externally </li></ul>Qualifications: <ul><li>PhD in biological, technical, or engineering field with 1-2 years post-doc/industry experience. BS and MS degree in a relevant biological, technical, or engineering field, with 10 years for BS, or 8 years for MS, of relevant professional experience may also be acceptable. </li><li>Strong background in tumor biology or immunology </li><li>Expertise in acute myeloid leukemia (AML) or solid tumor indications, allo-evasion, and/or T cell differentiations is strongly preferred </li><li>Demonstrated record of developing and optimizing various functional assays </li><li>Hands on knowledge of advanced flow cytometry methods, including multi-color (8+ color) panel design and analysis, as well as ICC for phospho-flow, cytokine, transcription factor studies. </li></ul>Requirements: <ul><li>Open communicator willing to ask questions and troubleshoot with colleagues </li><li>Detail-oriented with data-driven problem-solving skills </li><li>High degree of scientific integrity with a commitment to ethics and scientific rigor </li><li>Excellent written and verbal communication skills </li><li>Willingness to lead a small team of highly motivated scientists conducting innovative, fast-paced experiments </li><li>Industry experience strongly preferred </li></ul>Century Therapeutics Inc. is an Equal Employment Opportunity/Affirmative Action Employer - Minority/Female/Disability/Veteran. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or veteran status or any other characteristic protected by federal, state, or local law.

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